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Discipline Hopping x2: a next generation framework for multidisciplinary research between mathematics and regenerative medicine

Discipline Hopping x2：数学与再生医学之间多学科研究的下一代框架

基本信息

批准号：
EP/R013128/1
负责人：
Sarah Waters
金额：
$ 14.18万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FR013128%2F1
关键词：
Discipline Hopping x2 next generation

项目摘要

The overall goal of our reciprocal Discipline Hopping proposal is to explore and identify ways in which mathematical modelling may be embedded in all stages of the regenerative medicine pipeline, from the initial laboratory experiments, to quantitative assessment of the cellular microenvironment, to optimisation of tissue engineering protocols, through to successful translation to the clinic.The field of regenerative medicine has reached a key point in its development. As an exciting new advance brought in over the past 15-20 years, the potential for a major step change in healthcare therapy in the UK and worldwide was recognised. However, the complexity of the task was underestimated. To realise the full clinical potential offered by regenerative medicine, many facets of the field must be determined and defined to the standards and rigour of the scientific, regulatory and clinical community. While there is no doubt that many exciting and novel technologies and cell based approaches have been identified, they lack the quantitative approach and the predictive ability which is needed to make the long journey to the clinic.To truly embed mathematics in regenerative medicine, a deeper understanding of the interplay between the two fields is required, achievable through a collaborative approach for both scientists. In order for us to define a new field in Quantitative Regenerative Medicine, we need participation in, and exposure from, both disciplines across the divide. We will achieve this by spending dedicated time in each other's research Institutions. Outcomes from our research will include an opinion article, research publications in internationally-leading high-quality journals, workshops linked to national and international meetings, and a framework for a novel interdisciplinary Centre for Doctoral Training application, which will train a new generative of highly skilled researchers at the interface between mathematics and regenerative medicine.

我们互惠学科跳跃建议的总体目标是探索和确定将数学模型嵌入再生医学管道的所有阶段的方法，从最初的实验室实验，到细胞微环境的定量评估，到组织工程方案的优化，再到成功地转化到临床。再生医学领域已经到了其发展的关键时刻。作为过去15-20年来带来的令人兴奋的新进展，人们认识到了英国和世界各地医疗保健治疗发生重大变化的潜力。然而，这项任务的复杂性被低估了。为了实现再生医学提供的全部临床潜力，该领域的许多方面必须按照科学、法规和临床社区的标准和严格性来确定和定义。毫无疑问，已经发现了许多令人兴奋的新技术和基于细胞的方法，但它们缺乏长途跋涉进入临床所需的定量方法和预测能力。要真正将数学嵌入再生医学，需要对这两个领域之间的相互作用有更深的理解，这可以通过两位科学家的合作方法来实现。为了定义定量再生医学的一个新领域，我们需要参与和接触这两个学科，跨越鸿沟。我们将通过在彼此的研究机构中花费专门的时间来实现这一目标。我们的研究成果将包括一篇评论文章、在国际领先的高质量期刊上发表的研究文章、与国内和国际会议相联系的研讨会，以及一个新的跨学科中心的框架，该中心将为博士培训应用程序，该中心将培训新一代的高技能研究人员，在数学和再生医学之间的接口。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Predicting Bone Formation in Mesenchymal Stromal Cell-Seeded Hydrogels Using Experiment-Based Mathematical Modeling.

使用基于实验的数学模型预测间充质基质细胞接种的水凝胶中的骨形成。

DOI：
10.1089/ten.tea.2020.0027
发表时间：
2020
期刊：
Tissue engineering. Part A
影响因子：
0
作者：
Price JC
通讯作者：
Price JC

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.

DOI：
10.1038/s42003-023-04788-0
发表时间：
2023-05-18
期刊：
COMMUNICATIONS BIOLOGY
影响因子：
5.9
作者：
Mason, Jonathan H.;Luo, Lu;Reinwald, Yvonne;Taffetani, Matteo;Hallas-Potts, Amelia;Herrington, C. Simon;Srsen, Vlastimil;Lin, Chih-Jen;Barroso, Ines A.;Zhang, Zhihua;Zhang, Zhibing;Ghag, Anita K.;Yang, Ying;Waters, Sarah;El Haj, Alicia J.;Bagnaninchi, Pierre O.
通讯作者：
Bagnaninchi, Pierre O.

Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery.

磁性标记间充质基质细胞递送的实验和数学模型。