MICA: Exploiting in silico modelling to address the translational bottleneck in regenerative medicine safety
MICA:利用计算机模型解决再生医学安全性的转化瓶颈
基本信息
- 批准号:MR/T015489/1
- 负责人:
- 金额:$ 77.58万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Stem cells have great potential in medicine as then can grow into many different cell types in the body. One way of treating damaged tissues and organs is to transplant stem cells or cells derived from stem cells into the damaged organ - this kind of treatment is know as a cell therapy and an example of this used today is bone marrow transplantation. Whilst this treatment is successful for many diseases, in some cases this treatment does not work and the cells do not grow well. To develop new treatments for patients we require research tools that look at the safety of using cell therapies as well as look at the "immune response" e.g. how our body naturally reacts when a cell therapy is introduced. It is also important to look at how safe and efficient a cell therapy is. Our project team want to develop a range of tools that will answer these questions and speed up the process for developing new treatments for patients who are currently suffering form untreatable diseases. For this project, the team are going to look at liver disease. There are many problems with giving a patient a cell therapy: (1) making sure that the new cells end up at the site of injury/damaged tissue; (2) will the body can end up "attacking" these cells as part of the body's natural immune system; (3) do the cells attach onto the injured organ; (4) do the cells carry out their role within the body.The project team are going to use a combination of maths and biology in order to answer these questions. The project has the potential to produce a framework that could be used to help get new treatments out of a laboratory situation and heading towards being used as a treatment for a patient. Whilst liver disease is being used as a disease example for this project, the same tools could be used for a range of different diseases.
干细胞在医学上具有巨大的潜力,因为它可以在体内生长成许多不同的细胞类型。治疗受损组织和器官的一种方法是将干细胞或干细胞衍生的细胞移植到受损器官中 - 这种治疗被称为细胞疗法,当今使用的一个例子是骨髓移植。虽然这种治疗对于许多疾病是成功的,但在某些情况下这种治疗不起作用并且细胞生长不良。为了为患者开发新的治疗方法,我们需要研究工具来研究使用细胞疗法的安全性以及“免疫反应”,例如免疫反应。当引入细胞疗法时,我们的身体会如何自然反应。研究细胞疗法的安全性和有效性也很重要。我们的项目团队希望开发一系列工具来回答这些问题,并加快为目前患有无法治疗疾病的患者开发新疗法的进程。对于这个项目,该团队将研究肝脏疾病。为患者提供细胞疗法存在许多问题:(1)确保新细胞最终到达损伤/受损组织的部位; (2) 身体最终会“攻击”这些作为身体自然免疫系统一部分的细胞吗? (3) 细胞是否附着在受伤的器官上? (4)细胞在体内发挥其作用吗?项目团队将结合数学和生物学来回答这些问题。该项目有潜力产生一个框架,可用于帮助从实验室情况中获得新的治疗方法,并用于治疗患者。虽然肝病被用作该项目的疾病示例,但相同的工具可以用于一系列不同的疾病。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery.
磁性标记间充质基质细胞递送的实验和数学模型。
- DOI:10.1098/rsif.2020.0558
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Yeo EF
- 通讯作者:Yeo EF
Coupling Stokes Flow with Inhomogeneous Poroelasticity
非均匀孔隙弹性耦合斯托克斯流
- DOI:10.1093/qjmam/hbab014
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Taffetani M
- 通讯作者:Taffetani M
Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery
磁性标记间充质基质细胞递送的实验和数学模型
- DOI:10.1101/2020.10.27.356725
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Yeo E
- 通讯作者:Yeo E
A kinetic model of a polyelectrolyte gel undergoing phase separation
- DOI:10.1016/j.jmps.2021.104771
- 发表时间:2022-02-07
- 期刊:
- 影响因子:5.3
- 作者:Celora, Giulia L.;Hennessy, Matthew G.;Waters, Sarah L.
- 通讯作者:Waters, Sarah L.
Utilising an in silico model to predict outcomes in senescence-driven acute liver injury
利用计算机模型预测衰老驱动的急性肝损伤的结果
- DOI:10.1101/2023.10.11.561528
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Ashmore-Harris C
- 通讯作者:Ashmore-Harris C
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Sarah Waters其他文献
A mathematical model for single-cell cryopreservation
- DOI:
10.1016/j.cryobiol.2020.10.067 - 发表时间:
2020-12-01 - 期刊:
- 影响因子:
- 作者:
Mohit Dalwadi;Sarah Waters;Helen Byrne;Ian Hewitt - 通讯作者:
Ian Hewitt
The development, implementation and evaluation of Clinical Practice Guidelines in Gulf Cooperation Council (GCC) Countries
海湾合作委员会 (GCC) 国家临床实践指南的制定、实施和评估
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Sarah Waters - 通讯作者:
Sarah Waters
Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover
与 LC3 和多聚泛素链的相互作用将 nbr1 与自噬蛋白周转联系起来
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:3.5
- 作者:
Sarah Waters;K. Marchbank;E. Solomon;C. Whitehouse;M. Gautel - 通讯作者:
M. Gautel
Communicating echocardiography results to patients: a future role for the clinical scientist
将超声心动图结果传达给患者:临床科学家的未来角色
- DOI:
10.1530/erp-17-0033 - 发表时间:
2017-09-01 - 期刊:
- 影响因子:2.400
- 作者:
Jenna Smith;Sarah Waters;Brian Campbell;Chambers John - 通讯作者:
Chambers John
Graduate Preparation and Professional Development of Speech Language Pathology Students: A Grounded Theory Study
言语病理学学生的研究生准备和专业发展:扎根理论研究
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Sarah Waters - 通讯作者:
Sarah Waters
Sarah Waters的其他文献
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{{ truncateString('Sarah Waters', 18)}}的其他基金
MechAscan - A novel online mechanical assessment tool for manufacturing engineered tissues in regenerative medicine and drug discovery
MechAscan - 一种新型在线机械评估工具,用于制造再生医学和药物发现中的工程组织
- 批准号:
EP/P031218/1 - 财政年份:2018
- 资助金额:
$ 77.58万 - 项目类别:
Research Grant
Discipline Hopping x2: a next generation framework for multidisciplinary research between mathematics and regenerative medicine
Discipline Hopping x2:数学与再生医学之间多学科研究的下一代框架
- 批准号:
EP/R013128/1 - 财政年份:2018
- 资助金额:
$ 77.58万 - 项目类别:
Research Grant
Suicide Voices: Neoliberal Globalisation and Workplace Trauma
自杀的声音:新自由主义全球化和工作场所创伤
- 批准号:
AH/N004299/1 - 财政年份:2017
- 资助金额:
$ 77.58万 - 项目类别:
Fellowship
Flow in collapsible tubes: Computations, experiments and (at last!) a rational mathematical model for the onset of self-excited oscillations
塌陷管中的流动:计算、实验和(最后!)自激振荡发生的合理数学模型
- 批准号:
EP/D070910/2 - 财政年份:2007
- 资助金额:
$ 77.58万 - 项目类别:
Research Grant
New mathematical models for perfusion bioreactors in tissue engineering
组织工程中灌注生物反应器的新数学模型
- 批准号:
EP/D070635/2 - 财政年份:2007
- 资助金额:
$ 77.58万 - 项目类别:
Fellowship
Flow in collapsible tubes: Computations, experiments and (at last!) a rational mathematical model for the onset of self-excited oscillations
塌陷管中的流动:计算、实验和(最后!)自激振荡发生的合理数学模型
- 批准号:
EP/D070910/1 - 财政年份:2006
- 资助金额:
$ 77.58万 - 项目类别:
Research Grant
New mathematical models for perfusion bioreactors in tissue engineering
组织工程中灌注生物反应器的新数学模型
- 批准号:
EP/D070635/1 - 财政年份:2006
- 资助金额:
$ 77.58万 - 项目类别:
Fellowship
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