Novel low cost diagnostic tools and their impact in Africa

新型低成本诊断工具及其对非洲的影响

基本信息

  • 批准号:
    EP/R01437X/1
  • 负责人:
  • 金额:
    $ 202.02万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2018
  • 资助国家:
    英国
  • 起止时间:
    2018 至 无数据
  • 项目状态:
    已结题

项目摘要

Point of care testing is fundamental in delivering health and economic sustainability in the Global South. Our project will enable low cost, effective and accurate diagnosis of, in the first instance, two infectious diseases, namely malaria and schistosomiasis. This will be achieved using a novel very low cost paper diagnostic method that is able to quantify the infectious agent's DNA in a patient sample in a multiplexed assay. The platform will allow the measurement of several diseases at the same time, thereby increasing the efficiency of healthcare provision in often hard to reach settings, as well as establishing the species of the infectious agent (e.g. malaria), which will provide actionable information to healthcare professionals, where drugs have different levels of activity for different species, thus helping in reducing the potential emergence/increase of drug resistance. We have already demonstrated the potential for these low cost assays as being both sensitive and specific and we now wish to develop new engineering approaches to improve their performance (in terms of their speed and ease of use) and evidence their impact so that they can find widespread application in both rural and urban environments in Uganda and Sierra Leone, and other endemic countries. As the assays are sensitive and quantitative, they have the potential to be used not only in the treatment of individuals, but also in eradication programmes, such as those advocated by the London 2020 accord, enabling the surveillance of disease re/emergence. To help communicate the value of repeated treatments, we plan to develop new engagement tools based upon a novel mobile phone imaging platform that enables patients to visualise the infectious agent in a sample, and to see the outcome of interventions (whether these be through drug administration or physical/cultural changes such as access to improved sanitation or bed nets). We also propose to measure the impact of our novel diagnostic and imaging platforms by collection of suitable, realistic, logistically feasible metrics, and the potential impacts (including resources, health outcomes, employment, income) of the interventions. We will also feed these into newly developed and parameterised economic models to predict the long-term benefits specific interventions may have. Finally, integral to the proposed research is an ambitious programme of impact, which includes public engagement over infectious disease diagnosis and STEM and capacity strengthening. We will also explore routes to delivery of the technologies both in the UK, where the provision of low-cost point-of-care diagnostics is of significant interest (through our industrial partners), and in LMICs. Our ambition is to explore whether, through not-for-profit business planning, we can develop the correct interactions with Governments, Hospitals and Charities/NGOs, to test whether we are able to scale the manufacturing of these devices, such that they can be made in Africa, for Africa, by Africans.
护理点测试是在全球南方提供健康和经济可持续性的基础。我们的项目将使我们能够首先低成本、有效和准确地诊断两种传染病,即疟疾和血吸虫病。这将使用一种新的非常低成本的纸质诊断方法来实现,该方法能够在多重分析中对患者样本中的感染剂DNA进行量化。该平台将允许同时测量几种疾病,从而提高在往往难以到达的环境中提供医疗保健的效率,并建立传染病(如疟疾)的物种,这将向医疗专业人员提供可操作的信息,其中药物对不同物种具有不同的活性水平,从而有助于减少潜在的出现/增加抗药性。我们已经证明了这些低成本检测方法既敏感又特异的潜力,现在我们希望开发新的工程方法来提高它们的性能(就其速度和易用性而言),并证明其影响,以便它们能够在乌干达和塞拉利昂以及其他流行国家的农村和城市环境中得到广泛应用。由于这些分析是敏感和定量的,它们不仅有可能用于个人的治疗,而且还有可能用于根除方案,如《伦敦2020年协定》所倡导的方案,从而能够监测疾病的复发/浮现。为了帮助传达重复治疗的价值,我们计划基于一种新型的手机成像平台开发新的参与工具,使患者能够可视化样本中的传染病病原体,并查看干预的结果(无论是通过药物管理还是身体/文化变化,如获得更好的卫生条件或蚊帐)。我们还建议通过收集合适的、现实的、在后勤上可行的指标以及干预措施的潜在影响(包括资源、健康结果、就业、收入)来衡量我们新型诊断和成像平台的影响。我们还将把这些数据输入到新开发的参数经济模型中,以预测特定干预措施可能产生的长期效益。最后,拟议研究的组成部分是一项雄心勃勃的影响方案,其中包括公众参与传染病诊断和STEM以及加强能力。我们还将探索在英国和LMIC提供技术的途径,在英国,提供低成本的医疗诊断非常重要(通过我们的工业合作伙伴)。我们的目标是探索,通过非营利性的商业规划,我们是否能够与政府、医院和慈善机构/非政府组织建立正确的互动,以测试我们是否能够扩大这些设备的制造,以便它们可以在非洲制造,为非洲制造,由非洲人制造。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Schistosomiasis Control: Leave No Age Group Behind.
  • DOI:
    10.1016/j.pt.2020.04.012
  • 发表时间:
    2020-07
  • 期刊:
  • 影响因子:
    9.6
  • 作者:
    Faust CL;Osakunor DNM;Downs JA;Kayuni S;Stothard JR;Lamberton PHL;Reinhard-Rupp J;Rollinson D
  • 通讯作者:
    Rollinson D
Translating From Egg- to Antigen-Based Indicators for Schistosoma mansoni Elimination Targets: A Bayesian Latent Class Analysis Study.
  • DOI:
    10.3389/fitd.2022.825721
  • 发表时间:
    2022-02-18
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Clark J;Moses A;Nankasi A;Faust CL;Adriko M;Ajambo D;Besigye F;Atuhaire A;Wamboko A;Rowel C;Carruthers LV;Francoeur R;Tukahebwa EM;Lamberton PHL;Prada JM
  • 通讯作者:
    Prada JM
Gender-related differences in prevalence, intensity and associated risk factors of Schistosoma infections in Africa: A systematic review and meta-analysis.
  • DOI:
    10.1371/journal.pntd.0009083
  • 发表时间:
    2021-11
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Ayabina DV;Clark J;Bayley H;Lamberton PHL;Toor J;Hollingsworth TD
  • 通讯作者:
    Hollingsworth TD
Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis.
  • DOI:
    10.1186/s13148-022-01266-y
  • 发表时间:
    2022-04-11
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Good M;Chu T;Shaw P;Nolan LS;Wrobleski J;Castro C;Gong Q;DeWitt O;Finegold DN;Peters D
  • 通讯作者:
    Peters D
Smartphone-based DNA diagnostics for malaria detection using deep learning for local decision support and blockchain technology for security
  • DOI:
    10.1038/s41928-021-00612-x
  • 发表时间:
    2021-08-02
  • 期刊:
  • 影响因子:
    34.3
  • 作者:
    Guo, Xin;Khalid, Muhammad Arslan;Cooper, Jonathan M.
  • 通讯作者:
    Cooper, Jonathan M.
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Jonathan Cooper其他文献

On the Effect of Geometric Nonlinearity on the Dynamics of Flared Folding Wingtips
几何非线性对张开折叠翼尖动力学的影响
  • DOI:
    10.2514/1.c036877
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    F. Healy;R. Cheung;D. Rezgui;Jonathan Cooper;T. Wilson;A. Castrichini
  • 通讯作者:
    A. Castrichini
Experience report: a Haskell interpreter for cellML
经验报告:cellML 的 Haskell 解释器
Embracing the conceptual shift on new ways of experiencing the city and learning urban design: pedagogical methods and digital technologies
拥抱体验城市和学习城市设计新方式的概念转变:教学方法和数字技术
  • DOI:
    10.1080/13574809.2015.1071651
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    2.1
  • 作者:
    Regina Mapua Lim;Laura Novo de Azevedo;Jonathan Cooper
  • 通讯作者:
    Jonathan Cooper
A Doppler-based Human Activity Recognition System using WiFi Signals
使用 WiFi 信号的基于多普勒的人体活动识别系统
  • DOI:
    10.1109/sensors47087.2021.9639680
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Y. Ge;Shibo Li;Minjian Shentu;Ahmad Taha;Shuyuan Zhu;Jonathan Cooper;M. Imran;Q. Abbasi
  • 通讯作者:
    Q. Abbasi
Law, Policy, and Society Health Law Reproductive Tissue Transplants Defy Legal and Ethical Categorization 232
法律、政策和社会健康法生殖组织移植违反法律和伦理分类 232
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Rohrer;Valarie K. Blake;K. Shah;B. Hippen;B. Vladeċk;S. Florman;Jonathan Cooper
  • 通讯作者:
    Jonathan Cooper

Jonathan Cooper的其他文献

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{{ truncateString('Jonathan Cooper', 18)}}的其他基金

Quantum Imaging for Monitoring of Wellbeing & Disease in Communities
用于健康监测的量子成像
  • 批准号:
    EP/T021020/1
  • 财政年份:
    2021
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
MICA: Community Based Point-of-Need Integrated Diagnostics for SARS-CoV-2
MICA:基于社区的 SARS-CoV-2 需求点综合诊断
  • 批准号:
    MR/V035401/1
  • 财政年份:
    2021
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Window into the Mind: Handheld Spectroscopic Eye-safe Device (EyeD) for Neurodiagnostics
心灵之窗:用于神经诊断的手持式光谱眼安全设备 (EyeD)
  • 批准号:
    EP/V029940/1
  • 财政年份:
    2021
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Mobile Phone enabled Diagnostics for Infectious Disease Diagnosis: Low Cost Tools for Digital Health in East Africa
手机支持传染病诊断:东非数字健康的低成本工具
  • 批准号:
    EP/T029765/1
  • 财政年份:
    2020
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Development of multiplexed diagnostic biosensor for infectious reproductive diseases of cattle and buffaloes
牛和水牛传染性生殖疾病多重诊断生物传感器的开发
  • 批准号:
    BB/L00464X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Advanced Diagnostics using Phononics
使用 Phonics 进行高级诊断
  • 批准号:
    EP/K027611/1
  • 财政年份:
    2013
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Fellowship
13TSB_ENDANI_MilkED: Development of a point of need diagnostic test for infectious disease in milk
13TSB_ENDANI_MilkED:开发牛奶中传染病的需求点诊断测试
  • 批准号:
    BB/L011336/1
  • 财政年份:
    2013
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Electrophysiology chip on a microfluidic platform
微流控平台上的电生理芯片
  • 批准号:
    BB/H013369/1
  • 财政年份:
    2011
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Holographic Micro Flow Meter for Biological Sensing
用于生物传感的全息微流量计
  • 批准号:
    BB/E022243/1
  • 财政年份:
    2008
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant
Listening to the Micro-World
聆听微观世界
  • 批准号:
    EP/F040857/1
  • 财政年份:
    2008
  • 资助金额:
    $ 202.02万
  • 项目类别:
    Research Grant

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