Asymmetric Catalytic Photochemistry

不对称催化光化学

• 批准号: EP/R014833/1
• 负责人: Christopher Smith
• 金额: $ 12.66万
• 依托单位: University of Reading
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR014833%2F1
• 关键词: Asymmetric; Catalytic; Photochemistry

This proposed research will investigate a new general approach to Asymmetric Catalytic Photochemistry (ACP) for the synthesis of useful functional molecules such as drugs. Most people are familiar with reactions occurring when a molecule is heated up (e.g. cooking), but different reactions are possible using UV-light (photochemistry) and sunburn is an unfortunate consequence of this. We plan to use the unique reactivity of photochemistry, safely confined in a lightbox, to synthesize new functional molecules and will control the synthesis of these photochemical reactions by adding a small amount of a chiral catalyst to the reaction mixture. This chiral catalyst will allow us to selectively synthesize either right- or left-handed products, i.e. mirror images of each other, simply by changing the catalyst. The controlled synthesis of these handed-molecules is vital for our health and well-being since the enzymes and proteins in our body and pathogens, such as bacteria and viruses, selectively react to these chiral molecules. These new molecules that we make could become the drugs and pesticides of the future. ACP is a multi-disciplinary approach to address deficits in current chiral photochemical methodology and will develop a repeatable and scalable technology platform for further investigations. The ACP concept is particularly 'green' as it requires only small amounts of a chiral catalyst for control and uses UV-light to perform the reaction. This research will be highly significant to both academia and industry as it offers a general approach for the asymmetric synthesis of new functional chiral molecules. This proposal addresses a highly important and challenging concept within organic synthesis and will find immediate applications across synthetic chemistry.

这项研究将探索一种新的通用方法，不对称催化光化学（ACP）合成有用的功能分子，如药物。大多数人都熟悉当分子被加热时发生的反应（例如烹饪），但使用紫外线（光化学）可能会发生不同的反应，晒伤是一个不幸的后果。我们计划使用光化学的独特反应性，安全地限制在灯箱中，合成新的功能分子，并将通过向反应混合物中添加少量手性催化剂来控制这些光化学反应的合成。这种手性催化剂将使我们能够选择性地合成右手或左手产物，即彼此的镜像，只需改变催化剂。这些手性分子的受控合成对我们的健康和福祉至关重要，因为我们体内的酶和蛋白质以及病原体（如细菌和病毒）选择性地与这些手性分子反应。我们制造的这些新分子可以成为未来的药物和杀虫剂。ACP是一种多学科方法，用于解决当前手性光化学方法的不足，并将为进一步研究开发可重复和可扩展的技术平台。ACP概念是特别“绿色”的，因为它只需要少量的手性催化剂用于控制，并使用UV光进行反应。该研究为不对称合成新型功能手性分子提供了一条通用的途径，对学术界和工业界都具有重要意义。该提案解决了有机合成中一个非常重要且具有挑战性的概念，并将在合成化学中立即应用。

项目成果

A Homocoupling Approach to the Key Dione of CyMe4-BTPhen - Vital Ligands for Nuclear Clean-Up by the SANEX Process

CyMe4-BTPhen 关键二酮的同偶联方法 - SANEX 工艺核净化的重要配体

• DOI: 10.1055/a-1737-8610
• 发表时间: 2022
• 期刊: SynOpen
• 影响因子: 2.5
• 作者: Smith C