Household Transmission and Immunity to SARS-CoV-2 among Paediatric Clients of a Primary Care Center in a Low-resource Community in Rio de Janeiro

里约热内卢资源匮乏社区初级保健中心儿科患者的家庭传播和对 SARS-CoV-2 的免疫力

• 批准号: MR/V033530/1
• 负责人: Christopher Smith
• 金额: $ 78.09万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV033530%2F1
• 关键词: Household; Transmission; Immunity; SARS; CoV

Our aim is to study the household transmission dynamics of SARS-CoV-2 in a slum in Rio de Janeiro, Brazil and to estimate the immunity of the study population against the new virus. We will examine and test a sample of children and their families for SARS-CoV-2.Recruitment will take place at a primary health clinic, located in one of the poorest neighbourhoods of the city. We will recruit children 0 to 13 years of age who are brought to the clinic to receive free vaccinations. With the written informed consent from the child's guardian, we will collect the study samples. Afterwards we will visit the child's home to collect samples of all residents, with four follow-up visits in the first month, every three months during the first year and twice in the second year. We hope to uncover the role of children in the disease transmission.

我们的目的是研究SARS-CoV-2在巴西里约热内卢贫民窟的家庭传播动力学，并估计研究人群对新病毒的免疫力。我们将对儿童及其家庭进行SARS-CoV-2的抽样检查和测试。招募将在位于该市最贫困社区之一的初级卫生诊所进行。我们将招募0至13岁的儿童到诊所接受免费疫苗接种。在获得儿童监护人的书面知情同意后，我们将采集研究样本。之后，我们会到儿童的家中收集所有居民的样本，第一个月进行四次随访，第一年每三个月进行一次，第二年进行两次。我们希望揭示儿童在疾病传播中的作用。

项目成果

Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.

• DOI: 10.1590/0074-02760230069
• 发表时间: 2023
• 期刊: MEMORIAS DO INSTITUTO OSWALDO CRUZ
• 影响因子: 2.8
• 作者: Espindola, Otavio;Resende, Paola C.;Guaraldo, Lusiele;Calvet, Guilherme Amaral;Fuller, Trevon L.;Penetra, Stephanie Lema Suarez;Santos, Heloisa Ferreira Pinto;Pina-Costa, Anielle;da Silva, Michele Fernanda Borges;Moraes, Isabella Campos Vargas;Medeiros, Fernando;Whitworth, Jimmy;Smith, Christopher;Nielsen-Saines, Karin;Siqueira, Marilda M.;Brasil, Patricia
• 通讯作者: Brasil, Patricia

Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil.

• DOI: 10.1136/bmjopen-2022-067212
• 发表时间: 2022-12-07
• 期刊: BMJ open
• 影响因子: 2.9

Incidence of SARS-CoV-2 over four epidemic waves in a low-resource community in Rio de Janeiro, Brazil: A prospective cohort study.

• DOI: 10.1016/j.lana.2022.100283
• 发表时间: 2022-08
• 期刊: LANCET REGIONAL HEALTH-AMERICAS
• 作者: Carvalho, Marilia Sa;Bastos, Leonardo Soares;Fuller, Trevon;Cruz, Owaldo Goncalves;Damasceno, Luana;Calvet, Guilherme;Resende, Paola Cristina;Smith, Chris;Whitworth, Jimmy;Siqueira, Marilda;Brasil, Patricia
• 通讯作者: Brasil, Patricia

Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil.

• DOI: 10.1371/journal.pone.0250853
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Calvet GA;Pereira SA;Ogrzewalska M;Pauvolid-Corrêa A;Resende PC;Tassinari WS;Costa AP;Keidel LO;da Rocha ASB;da Silva MFB;Dos Santos SA;Lima ABM;de Moraes ICV;Mendes Junior AAV;Souza TDC;Martins EB;Ornellas RO;Corrêa ML;Antonio IMDS;Guaraldo L;Motta FDC;Brasil P;Siqueira MM;Gremião IDF;Menezes RC
• 通讯作者: Menezes RC

Repercussions of the COVID-19 pandemic on preventive health services in Brazil.

• DOI: 10.1016/j.ypmed.2021.106914
• 发表时间: 2022-03
• 期刊: Preventive medicine
• 影响因子: 5.1
• 作者: de Oliveira MM;Fuller TL;Gabaglia CR;Cambou MC;Brasil P;de Vasconcelos ZFM;Nielsen-Saines K
• 通讯作者: Nielsen-Saines K