Coordination chemistry approaches to societal issues: environment and health

海外旅行补助金（OTG）将汇集国际公认的实验室，以解决从新的抗癌化合物到形成具有理想环境特性（在垃圾填埋场更好地降解的能力）的塑料等问题。虽然OTG本身不会产生研究，但与中国和日本团体的讨论本身将导致研究。如果PI能够访问指定的团体，以便进行有效的面对面合作，并为进一步的发展铺平道路，那么所有项目都有更大的成功机会。本文确定了许多研究主题，这些主题将并行运行，即[1]设计用于塑料生产的新催化剂。这些塑料将是可生物降解的聚合物，以解决目前垃圾填埋场的问题。[2]新的金属基抗癌和/或成像剂将在船体的新的最先进的PET中心开发和筛选。[3]在铌上使用多齿阴离子配体以提供获得新复分解催化剂的途径。[4]评估钒基杯芳烃化合物作为多相催化剂用于各种工艺，包括二氧化碳和正丁烷的氧化脱氢;偏二氟乙烯的聚合也很有意义。[5]新型金属-金属键合化学及其在小分子活化例如炔活化中的应用。在这些项目中，在各个实验室进行的大部分合成工作将由在日本进行的分子建模（Escano，福井大学）指导。参与的六个远东研究小组已经被选中，因为他们为船体的PI小组提供了补充专业知识，包括有机合成，计算化学和材料评估，并将允许使用船体没有的最先进的设备，或者在英国其他地方确实很容易获得。

This Overseas Travel Grant (OTG) will bring together internationally recognised laboratories to tackle issues ranging from new anti-cancer compounds to forming plastics with desirable environmental properties (the ability to degrade better in landfill sites). Although the OTG is not going to be generating research in itself, the discussions with the Chinese and Japanese groups will themselves lead to the research. All of the projects stand a far greater chance of success if the PI can visit the named groups in order to execute effective face-to-face collaboration and pave the way for further developments. A number of research themes have been identified herein, which will run in parallel, namely [1] Designing new catalysts for plastic production. The plastics will be biodegradable polymers to address current issues with landfill sites. [2] New metal-based anti-cancer and/or imaging agents will be developed and screened in the new state-of-the-art PET centre at Hull. [3] Use of multi-dentate anionic ligands at niobium to provide access to new metathesis catalysts. [4] Evaluation of vanadium-based calixarene compounds to act as heterogeneous catalysts for a variety of processes to include oxidative dehydrogenation of ethylbenzene (with CO2) and that of n-butane; the polymerization of vinylidene difluoride is also of interest. [5] New metal-metal bonded chemistry and application thereof to the activation of small molecules, for example alkyne activation. Much of the synthetic work conducted in these projects in the various laboratories will be guided by molecular modelling conducted in Japan (Escano, Fukui University). The six Far East research groups involved have been selected given that they contribute complementary expertise to that available in the PIs group in Hull, with a mix of organic synthesis, computational chemistry and materials evaluation, and will allow access to state-of-the-art equipment that is not available in Hull or indeed readily available elsewhere the UK.