The Triple Way: Combining Pot, Atom and Step Economy (PASE) for Greener Organic Synthesis

三重方法：结合罐法、原子法和步骤经济 (PASE) 实现更绿色的有机合成

基本信息

批准号：
EP/C523970/2
负责人：
Paul Clarke
金额：
--
依托单位：
University of York
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FC523970%2F2
关键词：
Triple Way Combining Pot Atom

项目摘要

This project is aimed the development of a procedure for a one pot, atom and step economic synthesis of highly substituted THPs and piperidines. Atom economy, is the concept of every atom of each reagent being used is included in the desired product of the reaction. Step economy is the drive to reduce the number of synthetic steps (and hence the associated waste such as solvents used in the reaction, solvents used in work-up and product isolation, solvents used in product purification, silica gel or related substances used in chromatographic purification, contaminated aqueous waste generated from cleaning equipment and glassware, etc ) in the synthesis of any given target molecule. One pot reactions take the concept of step economy to its ultimate conclusion. That is the ability to complete an entire multi-step, multi-reaction synthesis in a single pot. If this can be achieved the problems of waste highlighted above would have been obviated. Application of these concepts embody Principles 1, 2, 5 and 8 of the Twelve Principles of Green Chemistry, and should ultimately lead to the `ideal synthesis', which is a one step, one pot, atom economic construction of a target molecule from cheap, renewable starting materials in a 100% yield.In this project we propose to combine our expertise in the synthesis of organic molecules with the general expertise in Green Chemistry in the School of Chemistry at the University of Nottingham. This project is aimed at combining atom and step economy for the first time for the synthesis of small and medium sized molecules. Firstly, we will apply this strategy to the synthesis of tetrahydropyrans (THP). Secondly, we will apply this strategy to the synthesis of piperidines. These molecules are of considerable importance to the pharmaceutical, agrochemical and biotech industries.This work is both adventurous and speculative making it appropriate for EPSRC funding. However, if successful it will lead to shorter, cleaner and greener synthetic routes to these important classes of molecules. We seek CRYSTAL/EPRRC funding for manpower and consumables to carry out a two year proof of principle study

该项目的目的是开发一个锅，原子和经济综合的方法，是高度替代的THP和哌啶的经济综合。原子经济是所需的每种试剂的每个原子的概念都包括在反应的所需产物中。步进经济是减少合成步骤数量的驱动力（因此，相关的废物，例如在反应中使用的溶剂，用于工作和产品隔离的溶剂，用于产品纯化中的溶剂，硅胶或色谱纯化中使用的相关物质，污染于任何给定目标分类的清洁设备和玻璃器皿等因清洁设备和玻璃器皿等产生的水性浪费的物质）。一个锅反应将步进经济的概念得出了最终的结论。这就是能够在单个锅中完成整个多步，多反应合成的能力。如果可以实现这一点，那么上面突出显示的废物问题将被消除。这些概念的应用体现了十二种绿色化学原理的原理1、2、5和8，并最终应导致“理想合成”，这是一个步骤，这是一个步骤，一个锅，一个锅，廉价，可再生的起始材料的目标分子的经济结构，以100％的收益率。诺丁汉大学。该项目旨在首次合成中小型分子的原子和步进经济。首先，我们将将这种策略应用于四氢吡喃（THP）的合成。其次，我们将将这种策略应用于哌啶的合成。这些分子对于药物，农业和生物技术行业至关重要。这项工作既冒险又投机，使其适合EPSRC资金。但是，如果成功，它将导致这些重要类别类别的分子较短，更清洁和更绿色的合成路线。我们寻求水晶/EPRRC资助人力和消耗品，以进行两年的主要研究证明