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The Triple Way: Combining Pot, Atom and Step Economy (PASE) for Greener Organic Synthesis

三重方法：结合罐法、原子法和步骤经济 (PASE) 实现更绿色的有机合成

基本信息

批准号：
EP/C523970/2
负责人：
Paul Clarke
金额：
--
依托单位：
University of York
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FC523970%2F2
关键词：
Triple Way Combining Pot Atom

项目摘要

This project is aimed the development of a procedure for a one pot, atom and step economic synthesis of highly substituted THPs and piperidines. Atom economy, is the concept of every atom of each reagent being used is included in the desired product of the reaction. Step economy is the drive to reduce the number of synthetic steps (and hence the associated waste such as solvents used in the reaction, solvents used in work-up and product isolation, solvents used in product purification, silica gel or related substances used in chromatographic purification, contaminated aqueous waste generated from cleaning equipment and glassware, etc ) in the synthesis of any given target molecule. One pot reactions take the concept of step economy to its ultimate conclusion. That is the ability to complete an entire multi-step, multi-reaction synthesis in a single pot. If this can be achieved the problems of waste highlighted above would have been obviated. Application of these concepts embody Principles 1, 2, 5 and 8 of the Twelve Principles of Green Chemistry, and should ultimately lead to the `ideal synthesis', which is a one step, one pot, atom economic construction of a target molecule from cheap, renewable starting materials in a 100% yield.In this project we propose to combine our expertise in the synthesis of organic molecules with the general expertise in Green Chemistry in the School of Chemistry at the University of Nottingham. This project is aimed at combining atom and step economy for the first time for the synthesis of small and medium sized molecules. Firstly, we will apply this strategy to the synthesis of tetrahydropyrans (THP). Secondly, we will apply this strategy to the synthesis of piperidines. These molecules are of considerable importance to the pharmaceutical, agrochemical and biotech industries.This work is both adventurous and speculative making it appropriate for EPSRC funding. However, if successful it will lead to shorter, cleaner and greener synthetic routes to these important classes of molecules. We seek CRYSTAL/EPRRC funding for manpower and consumables to carry out a two year proof of principle study

该项目旨在开发一种一锅、原子、分步经济合成高度取代的THP和哌啶的方法。原子经济是指所使用的每种试剂的每个原子都包含在所需反应产物中的概念。步骤经济是指在任何给定目标分子的合成中减少合成步骤的数量（从而减少相关废物，例如反应中使用的溶剂、后处理和产品分离中使用的溶剂、产品纯化中使用的溶剂、色谱纯化中使用的硅胶或相关物质、清洁设备和玻璃器皿产生的受污染的水性废物等）。一锅反应将步骤经济的概念推向了最终的结论。这是在一个锅中完成整个多步骤、多反应合成的能力。如果能够实现这一点，上述浪费问题就可以避免。这些概念的应用体现了绿色化学十二原则中的原则 1、2、5 和 8，并最终应导致“理想合成”，即用廉价、可再生的起始材料以 100% 的产率一步、一锅、原子经济地构建目标分子。在这个项目中，我们建议将我们在有机分子合成方面的专业知识与化学学院绿色化学的一般专业知识相结合。诺丁汉大学。该项目旨在首次将原子和步骤经济结合起来用于中小分子的合成。首先，我们将该策略应用于四氢吡喃（THP）的合成。其次，我们将该策略应用于哌啶的合成。这些分子对于制药、农化和生物技术行业非常重要。这项工作既具有冒险性又具有投机性，因此适合 EPSRC 资助。然而，如果成功的话，这将为这些重要分子类别提供更短、更清洁和更环保的合成路线。我们寻求 CRYSTAL/EPRRC 资金用于人力和消耗品，以进行为期两年的原理研究证明