Synthetic Studies on the Natural Products FR182877 and Hexacyclinic Acid

天然产物FR182877和六环酸的合成研究

• 批准号: GR/S77301/02
• 负责人: Paul Clarke
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=GR%2FS77301%2F02
• 关键词: Synthetic; Studies; Natural; Products; FR182877

Using novel reactions and strategies as well as those developed in the group we intend to synthesise the cytotoxic polyketide natural product hexacyclinic acid. The ABC-rings will be formed by use of a Diels-Alder/reductive annulation approach, while the DEF-rings will be constructed by using our transannular iodocyclisation reaction. Application of this strategy to the total synthesis of the related natural product FR182877 and selected novel analogues of these molecules will enable SAR investigations to commence.

利用新的反应和策略，以及那些在小组中开发的，我们打算合成细胞毒性聚酮天然产物己烯酸。abc环将通过Diels-Alder/还原环化方法形成，而def环将通过我们的跨环碘环化反应构建。将这一策略应用于相关天然产物FR182877的全合成和这些分子的新类似物的选择将使SAR研究开始。

项目成果

Improved Synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol

(2E,4Z)-6-(苄氧基)-4-溴六-2,4-二烯-1-醇的改进合成

• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Clarke P (Author)