A National Network for Applications of High-Field NMR in the Life and Physical Sciences

高场核磁共振在生命和物理科学中应用的国家网络

• 批准号: EP/R030065/1
• 负责人: Dusan Uhrin
• 金额: $ 174.31万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FR030065%2F1
• 关键词: National; Network; Applications; Field; NMR

Nuclear Magnetic Resonance (NMR) spectroscopy is a very powerful technique used in many fields of physical and life sciences, including all branches of chemistry, material sciences and biology. It provides wealth of information about (bio)molecules in solution and materials and insoluble molecules in solid state.Increasing the operating frequency of NMR spectrometers leads to higher sensitivity and resolution. Both are required when working with small (tens of micrograms) amounts of sample, or with large biomacromolecules (proteins, DNA, carbohydrates). Similarly, and especially for some nuclei, solid- state NMR accrues additional benefits at higher frequencies. There are therefore instances where only high-field spectrometers can solve a particular problem. However, very-high field and ultra-high field spectrometers come at a cost, largely associated with the development and production of their superconducting magnets. It is therefore imperative that such instrumentation is used efficiently through sharing by many research groups. Modern NMR spectrometers are versatile pieces of equipment that can be customised to tackle a range of samples, so sharing across disciplines and applications (e.g. liquid- vs solid-state) is possible. Spectroscopists from across the UK working in a wide-range of scientific disciplines have therefore agreed to work towards a coordinated strategy for sharing very-high and ultra-high field NMR equipment to underpin fundamental and applied sciences in a wide range of areas, ranging from battery and solar panel research, enzyme catalysis, drug discovery, food security, understanding disease or characterisation of environmental matrices. By sharing technologically advanced methodologies, the impact on the UK society will be maximised, both in the academia and industry, thus contributing to the UK economic viability and overall well-being.As part of this strategy, Scottish NMR researchers representing all Scottish universities and the CRUK Beatson Institute, have decided to establish Scottish High Field (SHF) NMR Centre around the upgraded 800 MHz NMR spectrometer housed in the SoC at UoE. This upgrade will equip the spectrometer with up-to-date NMR capabilities for liquid- and solid-state experiments. This involves installation of two CryoProbes, MAS controller, high power 1H amplifier and three solid-state probes in Year 1, followed by the upgrade of the console in Year 3 to guarantee continued operation of the Centre beyond the duration of the grant.Equipping this spectrometer with the latest technology and utilising the existing magnet is the most economical option that will fulfil our aim: to provide cutting edge support in liquid- and solid-state NMR to physical and life sciences researchers to deliver significant academic and industrial impact. The measurement time on this upgraded 800-MHz liquids/solid-state NMR spectrometer will be shared between researchers from all Scottish universities, CRUK Beatson Institute and UoE researchers. Sustained operation of the Centre will be guaranteed by the financial support of participating institutions and umbrella organisations of life and chemical sciences in Scotland, SULSA and ScotCHEM. Importantly, the Centre will be operated by staff from all participating institutions.Using the Centre as the focal point, a hub and spoke model will be used to manage access to the mid- to high-magnetic field NMR spectrometers in Scotland. This will optimise access to NMR equipment and facilitate access to ultra-high field spectrometers in England, foster day-to-day cooperation, ensure exchange of information and dissemination of best practise.The SHF NMR Centre will transform the way high-field NMR is applied to chemistry, biology, environmental and material sciences in academia and industry. It will form a platform for interactions with other regional and national very-high field and ultra-high field UK NMR centres.

核磁共振（NMR）光谱是一种非常强大的技术，用于许多物理和生命科学领域，包括化学，材料科学和生物学的所有分支。它提供了有关（生物）分子在固态下的（生物）分子和不溶性分子中的丰富信息。提高NMR光谱仪的工作频率会导致更高的敏感性和分辨率。当使用少量（数十微克）样品或大型生物乳清分子（蛋白质，DNA，碳水化合物）时，都需要两者。同样，尤其是对于某些核，固态NMR在较高的频率下具有额外的好处。因此，在某些情况下，只有高场光谱仪才能解决特定问题。但是，高电场和超高的田间光谱仪的成本很大，这与超导磁铁的发展和生产基本上有关。因此，必须通过许多研究小组共享有效地使用这种仪器。现代的NMR光谱仪是可以自定义以解决一系列样品的多功能设备，因此可以跨学科和应用（例如液体与固态）共享。因此，来自英国各地在广泛科学学科工作的光谱师已同意采取协调的策略，以共享非常高和超高的现场NMR设备，以支撑基础和应用科学，并在各个领域，包括电池和太阳能研究，酶促催化性，疾病的疾病，疾病，疾病，综合疾病，包括电池和太阳能研究。通过共享技术先进的方法论，对英国社会的影响将在学术界和行业中最大化，从而为英国的经济生存能力和整体福祉做出了贡献。作为这一策略的一部分，苏格兰NMR的研究人员代表了苏格兰大学的所有苏格兰大学和Cruk Beatson Institute，他们决定建立苏格兰高地（Scottish High Field）（Scottish High Field）（Shf Field）（SHF）围绕NMR围绕着nmr围绕着800 000的nmz nmz。 Soc在Uoe。该升级将为光谱仪提供最新的NMR功能，用于液态和固态实验。这涉及在第1年安装两个冷冻探针，MAS控制器，高功率1H放大器和三个固态探针，然后在第3年安装控制台的升级，以确保中心的持续运行，超过赠款的持续时间。将该光谱仪与最新的技术和固定的磁铁相提并论，并提供了较低的磁铁，并提供了固定的范围，以实现我们的目标，以实现我们的目标：产生重大的学术和工业影响。该升级的800 MHz液体/固态NMR光谱仪的测量时间将在来自苏格兰大学，Cruk Beatson Institute和UOE研究人员的研究人员之间共享。该中心的持续运营将由苏格兰，苏尔萨和苏格兰人的生活和化学科学组织的财政支持和伞组织的财政支持来保证。重要的是，该中心将由所有参与机构的员工进行操作。将中心作为焦点，将使用集线器和辐条模型来管理苏格兰中中部至高磁场NMR光谱仪的访问。这将优化对NMR设备的访问，并促进英格兰的超高野外光谱仪的访问，培养日常合作，确保信息交换和最佳实践传播。SHFNMR中心将改变高档NMR在化学，生物学，环境，环境和材料科学学院和工业学院的应用方式。它将形成与其他地区和国家高级领域以及UK UK NMR中心互动的平台。

项目成果

Monitoring off-resonance signals with SHARPER NMR - the MR-SHARPER experiment.

使用 SHARPER NMR 监测非共振信号 - MR-SHARPER 实验。

• DOI: 10.1039/d2an00134a
• 发表时间: 2022
• 期刊: The Analyst
• 作者: Davy M

Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3.

• DOI: 10.1021/acsinfecdis.2c00445
• 发表时间: 2022-12-09
• 期刊: ACS INFECTIOUS DISEASES
• 影响因子: 5.3
• 作者: Hind, Charlotte;Clifford, Melanie;Woolley, Charlotte;Harmer, Jane;McGee, Leah M. C.;Tyson-Hirst, Izaak;Tait, Henry J.;Brooke, Daniel P.;Dancer, Stephanie J.;Hunter, Iain S.;Suckling, Colin J.;Beveridge, Rebecca;Parkinson, John A.;Sutton, J. Mark;Scott, Fraser J.
• 通讯作者: Scott, Fraser J.