A Fully-Automated Robotic System For Intelligent Chemical Reaction Screening

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Robotic systems are changing the way in which we manipulate, control and manufacture materials that are of central importance to society at large. Here, we will take advantage of a state of the art robotic system (Chemspeed Technologies ISYNTH, a Swiss-based technology), based at the University of York to transform the way that chemists (and potentially other scientists) develop new reactions, drawing on its high-throughput reaction screening capability. The ISYNTH robotic system, alongside other analytical instrumentation, will support studies in (a) reaction mechanisms, (b) reaction optimisation, (c) novel route and compound discovery. Reliably capturing reaction data, and its statistical analysis, will be important in ensuring that our project is successful. All data generated from the project will be accessible through a common data repository, providing a rich source of information for future scientists to examine. We will provide a highly-instrumented and data intensive system that will accelerate workflow, productivity, accuracy, and precision in reaction screening for the Chemistry and Chemical Engineering communities.