Very-High Field NMR in the Physical and Life Sciences at the University of Liverpool

利物浦大学物理和生命科学领域的甚高场核磁共振

• 批准号: EP/S013393/1
• 负责人: Frédéric Blanc
• 金额: $ 162.8万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS013393%2F1
• 关键词: Very; Field; NMR; Physical; Life

The objectives of the proposal are to upgrade and reconfigure the existing 800 MHz solution-state NMR spectrometer to a dual solution-solid NMR spectrometer. This dual configuration is similar to other NMR systems successfully used worldwide and is strategically differentiated from any of the existing UK high field provision. The upgraded system will provide opportunities to do new science not previously possible in Liverpool and the UK, in both academia and industry. In addition, the new system will become one component of the UK hub and spoke network of NMR instrumentation, with up to 30% of its time offered to the wider UK research community across the physical and life sciences, and is configured to complement other high field instruments (> 600 MHz), providing the flexibility for NMR infrastructure at the highest available field to respond to changes in research priorities and opportunities.NMR spectroscopy is the most versatile of all the analytical tools; it provides insights into molecular structure, dynamics, and interactions. The higher sensitivity and resolution delivered with very-high field NMR are transformative, providing information not accessible at lower field strength.The new dual solution-solid capabilities will support, extend and enhance research activities where there is excellence in the region and UK-wide (see Academic Beneficiaries) such as advanced chemical- and bio- materials, renewable energy, industrial biotechnology, personalised medicine and human/animal health. They will also strengthen and/or catalyse new academic-industrial collaborations, focusing on and exploiting areas of priority to the region and the UK. Examples include:(1) Structure determination of biological and chemical molecules and supra-molecular aggregates in solution and solid states;(2) Folding of linear polypeptides into complex biologically-active 3D structures, and the ways in which these processes can be altered or subverted in neurodegenerative diseases and cancer;(3) Catalytic processes, and the detailed analysis of the structure and dynamics of complex materials;(4) Metabolism within intact cells and organisms.UK research support targets strengthening the UK's competitive position in key priority areas. By upgrading to state-of-the-art instrumentation, the proposed 800 MHz upgrade will enable UK research communities to continue to make major contributions across the range of research challenges aligned with national agendas and strategic priorities, and to respond rapidly and flexibly to initiatives such as the Industrial Strategy Challenge and the Global Challenges Research Funds.We will deliver on this major investment in NMR by:(1) Progressing a challenging scientific agenda based on national priorities such as advanced materials, renewable energy, industrial biotechnology and synthetic biology, and core health challenges;(2) Ensuring that the UK is at the forefront of NMR technique development in both solution and solid state, by capitalising on our collective knowledge and experience, and providing training to the community through courses and summer schools;(3) Attracting industrial support, partnerships and engagement, founded upon a strong collective track record of using our scientific capabilities and assets to support economic growth;(4) Maximising the effective use of capital assets to ensure efficient provision of NMR access, building on our pioneering experience in equipment sharing of the N8, and operating and managing national facilities, within a long-term sustainability plan;(5) Aligning with the core individual institutional strategy of the University, as demonstrated by substantial institutional contributions towards the costs;(6) Developing annual reporting systems and symposia to disseminate findings and open new research strategies, and monitoring performance using defined Key Performance Indicators.

该方案的目标是将现有的800 MHz溶液态核磁共振光谱仪升级和重新配置为双溶液-固体核磁共振光谱仪。这种双重配置与全球成功使用的其他核磁共振系统相似，在战略上与英国现有的任何高油田供应都有所区别。升级后的系统将为利物浦和英国学术界和工业界提供以前无法实现的新科学研究机会。此外，新系统将成为英国核磁共振仪器轮辐网络的一个组成部分，其30%的时间将提供给更广泛的英国物理和生命科学研究界，并配置为补充其他高场仪器（> 600 MHz），为最高可用领域的核磁共振基础设施提供灵活性，以响应研究优先级和机会的变化。核磁共振波谱是所有分析工具中最通用的；它提供了对分子结构、动力学和相互作用的见解。高场核磁共振带来的更高灵敏度和分辨率具有变革性，提供了在低场强下无法获得的信息。新的双重解决方案-固体能力将支持、扩展和加强在该地区和全英国有卓越的研究活动（见学术受益人），如先进的化学和生物材料、可再生能源、工业生物技术、个性化医学和人类/动物健康。他们还将加强和/或促进新的学术-工业合作，重点关注和开发该地区和英国的优先领域。例如：(1)溶液和固体状态下生物和化学分子及超分子聚集体的结构测定；(2)线性多肽折叠成复杂的生物活性3D结构，以及这些过程在神经退行性疾病和癌症中被改变或颠覆的方式；(3)催化过程，复杂材料的结构和动力学的详细分析；(4)完整细胞和有机体内的代谢。英国研究支持的目标是加强英国在关键优先领域的竞争地位。通过升级到最先进的仪器，拟议的800 MHz升级将使英国研究社区能够继续在与国家议程和战略重点一致的研究挑战范围内做出重大贡献，并迅速灵活地响应工业战略挑战和全球挑战研究基金等倡议。我们将通过以下方式实现对NMR的重大投资：(1)根据国家优先事项推进具有挑战性的科学议程，如先进材料、可再生能源、工业生物技术和合成生物学以及核心健康挑战；(2)通过利用我们的集体知识和经验，并通过课程和暑期学校向社区提供培训，确保英国在溶液和固态核磁共振技术发展方面处于领先地位；(3)在利用我们的科学能力和资产支持经济增长的良好集体记录的基础上，吸引产业支持、伙伴关系和参与；(4)最大限度地有效利用资本资产，以确保有效提供核磁共振访问，在长期可持续性计划中，利用我们在N8设备共享和国家设施运营和管理方面的开创性经验；(5)符合大学个别机构的核心策略，由机构对成本作出大量贡献证明；(6)制定年度报告制度和专题讨论会，以传播研究成果和开辟新的研究战略，并使用确定的关键绩效指标监测绩效。

项目成果

Interfacial bonding between a crystalline metal-organic framework and an inorganic glass

结晶金属有机骨架与无机玻璃之间的界面结合

• DOI: 10.26434/chemrxiv-2023-4czjx
• 发表时间: 2023
• 作者: Castillo C

Local Structure in Disordered Melilite Revealed by Ultrahigh Field 71 Ga and 139 La Solid-State Nuclear Magnetic Resonance Spectroscopy

超高场 71 Ga 和 139 La 固态核磁共振波谱揭示无序黄长石的局域结构

• DOI: 10.1002/cphc.202300934
• 发表时间: 2024
• 期刊: ChemPhysChem
• 影响因子: 2.9
• 作者: Corti L

Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.

• DOI: 10.1039/d2ra01463g
• 发表时间: 2022-04-07
• 期刊: RSC advances
• 影响因子: 3.9
• 作者: London JA;Taylor SL;Barsukov I;Cartmell A;Yates EA
• 通讯作者: Yates EA

Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions.

Tensin3与塔林的相互作用驱动了与纤连蛋白相关的原纤维粘附的形成。

• DOI: 10.1083/jcb.202107022
• 发表时间: 2022-10-03
• 期刊: The Journal of cell biology

Interfacial Bonding between a Crystalline Metal-Organic Framework and an Inorganic Glass.

• DOI: 10.1021/jacs.3c04248
• 发表时间: 2023-10-25
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Castillo-Blas, Celia;Chester, Ashleigh M.;Cosquer, Ronan P.;Sapnik, Adam F.;Corti, Lucia;Sajzew, Roman;Poletto-Rodrigues, Bruno;Robertson, Georgina P.;Irving, Daniel J. M.;McHugh, Lauren N.;Wondraczek, Lothar;Blanc, Frederic;Keen, David A.;Bennett, Thomas D.
• 通讯作者: Bennett, Thomas D.