A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntingtons disease

亨廷顿病预诊断和有症状个体的认知和神经影像比较研究

• 批准号: nhmrc : 606650
• 负责人: Dr Andrew Churchyard
• 金额: $ 39.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comparative-cognitive-neuroimaging-huntingtons-disease/95844
• 关键词: comparative; cognitive; neuroimaging; study; pre

Huntington's disease (HD) is characterized by motor, cognitive and psychiatric disturbance. Neuroimaging techniques provide a range of measures that can characterize underlying brain changes. This study will use a range of clinical, behavioural, and brain imaging techniques to uncover the most sensitive and reliable marker of change in both pre diagnostic and early symptomatic HD. Therapeutic interventions can only be tested once markers have been identified.

亨廷顿病(HD)以运动、认知和精神障碍为特征。神经成像技术提供了一系列测量方法，可以表征潜在的大脑变化。这项研究将使用一系列临床、行为和脑成像技术来揭示诊断前和早期症状HD最敏感和最可靠的变化标志。只有在确定了标志物之后，才能对治疗干预措施进行测试。