A longitudinal neuroimaging study investigating reorganisation of cerebellar-cerebral networks in Friedreich ataxia

纵向神经影像研究调查弗里德赖希共济失调中小脑-大脑网络的重组

• 批准号: nhmrc : 1046037
• 负责人: Dr Andrew Churchyard
• 金额: $ 54.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/longitudinal-neuroimaging-study-friedreich-ataxia/111814
• 关键词: longitudinal; neuroimaging; study; investigating; reorganisation

Friedreich ataxia (FRDA) causes debilitating motor and cognitive deficits. We propose a longitudinal multi-modal magnetic resonance (MR) imaging study to measure different types of tissue in the brain in this disease. We seek to understand how the brain reorganises itself due to cell loss in the spinal cord, cerebellum and cerebral cortex. This study will establish sensitivity of a range of MR imaging measures as potential biomarkers for use in large multi-centre drug trials in this disease.

Friedreich共济失调(FRDA)会导致衰弱的运动和认知障碍。我们提出了一种纵向多模式磁共振(MR)成像研究来测量这种疾病中不同类型的脑组织。我们试图了解由于脊髓、小脑和大脑皮层中的细胞丢失，大脑是如何自我重组的。这项研究将建立一系列磁共振成像指标的敏感性，作为潜在的生物标记物，用于治疗这种疾病的大型多中心药物试验。