Comparative and Evolutionary Genomics of Schistosomes –Identifying Genes Associated with Parasitism, and Novel Drug and Vaccine Targets

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Schistosomiasis remains an important cause of human illness and death globally. My project proposes comparative genomics and evolutionary analysis of recently sequenced schistosome taxa and all publicly available flatworm genomes. The study will provide novel insights into identifying gene functions and pathways important for the parasite-host interaction, reveal novel candidate anti-schistosome drug or vaccine targets, and identify genes associated with bladder tumorogenesis in S. haematobium.