Bioinformatics for comparative and evolutionary genomics

比较和进化基因组学的生物信息学

• 批准号: 250391-2011
• 负责人: Csuros, Miklos
• 金额: $ 1.75万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547620
• 关键词: Bioinformatics; comparative; evolutionary; genomics

The proposed research project focuses on computational method development in genomics. The main biological questions adressed by the methods revolve around the interplay between evolutionary processes acting on different functional and non-functional elements. I will in particular focus on the evolution of homolog gene families and of eukaryotic gene structure. The project aims to develop novel computational methods to study the gain and loss of spliceosomal introns, or the gain and loss of genes. Relying on sophisticated mathematical models of gains and losses in a phylogenetic context, the methods are expected to shed light on selection forces that shaped modern genomes, and to aid in functional gene annotations.

拟议的研究项目侧重于基因组学中计算方法的发展。这些方法解决的主要生物学问题围绕着作用于不同功能和非功能元素的进化过程之间的相互作用。我将特别关注同源基因家族和真核基因结构的进化。该项目旨在开发新的计算方法来研究剪接体内含子的得失，或基因的得失。这些方法依赖于在系统发育背景下关于得失的复杂数学模型，预计将阐明塑造现代基因组的选择力量，并有助于功能基因注释。