Comparing pneumococcal vaccines in a high risk population: a randomised controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

比较高危人群中的肺炎球菌疫苗：一项关于免疫原性、安全性以及对巴布亚新几内亚婴儿携带肺炎球菌结合疫苗和多糖疫苗的影响的随机对照试验

• 批准号: nhmrc : GNT1087200
• 负责人: A/Pr Deborah Lehmann
• 金额: $ 100.96万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comparing-pneumococcal-vaccines-new-guinea/1345693
• 关键词: Comparing; pneumococcal; vaccines; risk; population

Pneumococcal disease is a major cause of pneumonia and meningitis in infants in developing countries in particular resulting in an estimated 800,000 deaths each year. This project will study how well pneumococcal vaccines perform in 260 high-risk infants in Papua New Guinea. We will examine how well the vaccines stimulate protective immunity and reduce babies carrying the pneumococcal bacteria in their nose and how long this immunity lasts for. The study will inform global immunisation policy.

肺炎球菌病是导致发展中国家婴儿肺炎和脑膜炎的主要原因，估计每年造成80万人死亡。该项目将研究肺炎球菌疫苗在巴布亚新几内亚260名高危婴儿中的效果。我们将检查疫苗刺激保护性免疫的效果如何，减少鼻子中携带肺炎球菌的婴儿，以及这种免疫持续多长时间。这项研究将为全球免疫政策提供参考。