Protecting Patients with Glomerular Disease from Vaccine-Preventable Infections
保护肾小球疾病患者免受疫苗可预防的感染
基本信息
- 批准号:10571899
- 负责人:
- 金额:$ 20.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-15 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdultAdvisory CommitteesAgeAntibioticsAntibodiesAntibody titer measurementAttenuatedBiological AssayBiopsyCause of DeathCell physiologyCharacteristicsChildClinicalCommunicable DiseasesComplementDataData AnalysesDatabasesDevelopmentDiseaseEffectivenessEpidemiologyExposure toFoundationsFrequenciesGoalsGuidelinesHealthcareIgG DeficiencyImmuneImmune responseImmunityImmunoglobulinsImmunosuppressionImpairmentIncidenceIndividualInfectionInfection preventionInfluenzaKidney DiseasesLeadLower Respiratory Tract InfectionMeasurementMeasuresMediatingMentorshipMethodsMonitorMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNephrotic SyndromeParticipantPatientsPharmaceutical PreparationsPneumococcal InfectionsPneumococcal vaccinePopulationPreparationPrevention MeasuresPrevention strategyPreventive measureProspective, cohort studyProteinuriaRare DiseasesRecommendationRegimenRenal functionRenal glomerular diseaseResearchResearch DesignResourcesRisk FactorsSample SizeScientistStatistical MethodsStreptococcus pneumoniaeTestingTimeTrainingVaccinatedVaccinationVaccinesWorkcareercareer developmentclinical practicecohortcost effectiveepidemiology studyexperiencehealth care service utilizationhigh riskhigh risk populationhospital careimmunogenicityin vivoinfluenza infectioninfluenza virus vaccinelongitudinal analysislongitudinal datasetmortalitypatient populationpragmatic trialprophylacticprospectiveseroconversionurinaryvaccination strategyvaccine effectivenessvaccine immunogenicityvaccine response
项目摘要
ABSTRACT
Influenza and pneumococcal infections occurring in individuals with glomerular disease are preventable
contributors to excess healthcare utilization, morbidity, and mortality, and occur at a rate approximately 30 times
higher among individuals with glomerular diseases compared to the general US population. Vaccination is a
powerful and cost-effective method to reduce infectious burden, however, vaccine immunogenicity and
effectiveness have not been adequately studied in this high-risk patient population. Vaccination may not yield
protective or sustained immune responses in individuals with glomerular disease as a result of exposure to
immunosuppressive medications, altered immune cell function, and urinary loss of immunoglobulin and
complement factors. As a result, there remain pressing questions regarding whether these antibodies confer in-
vivo protection from influenza and pneumococcal infection. Evidence gaps that need to be addressed in
preparation for pragmatic trials focused on infection-prevention measures in this population include frequency of
administration of recommended vaccines, pervasiveness of infectious complications, and rates of influenza and
pneumococcal vaccine seroconversion and seroprotection. Prior studies have been limited by small sample size,
insufficiently characterized cohorts, and the use of assays that measure non-opsonic, and thus potentially non-
functional, antibodies.
The objective of this proposal is to describe the association of influenza and pneumococcal vaccination with
influenza and pneumococcal infections and describe functional vaccine immunogenicity in patients with
glomerular disease. Three projects have been proposed to achieve this objective: an analysis of influenza and
pneumococcal vaccine use and effectiveness in a nationwide healthcare claims database (MarketScan®), a
study examining vaccine immunogenicity in the multicenter NIDDK-sponsored Cure Glomerulonephropathy
(CureGN) study, and creation of a multicenter cohort to examine 23-valent pneumococcal vaccine
immunogenicity in children with nephrotic syndrome. The primary hypothesis is that, independent of kidney
function, rates of influenza and pneumococcal infection and suboptimal vaccine response will be higher in
individuals with active glomerular disease, greater immunosuppression exposure, greater proteinuria, and
younger age. Dr. Glenn’s career development goals include gaining advanced training in statistical methods and
epidemiologic study design, with a focus on the analysis of longitudinal datasets, healthcare claims data, and
multicenter vaccine immunogenicity studies. Dr. Glenn will receive mentorship from Dr. Amy Mottl and Dr. Ronald
Falk, both experts in the field of glomerular kidney disease. Additionally, Dr. Glenn will have a scientific advisory
committee comprised of experts in vaccine immunogenicity, infectious disease, healthcare claims data analysis,
and epidemiology. This work will inform the development of an R01 application in which Dr. Glenn leads a
pragmatic trial investigating pneumococcal vaccination strategies among children with nephrotic syndrome.
摘要
项目成果
期刊论文数量(0)
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Dorey Glenn其他文献
Dorey Glenn的其他文献
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{{ truncateString('Dorey Glenn', 18)}}的其他基金
Protecting Patients with Glomerular Disease from Vaccine-Preventable Infections
保护肾小球疾病患者免受疫苗可预防的感染
- 批准号:
10445593 - 财政年份:2022
- 资助金额:
$ 20.14万 - 项目类别:
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