Complementary medicines based on propolis produced by honeybees from Australian

由蜜蜂生产的蜂胶是一种非常复杂的混合物，其化学成分因其植物来源而异。蜜蜂采集叶芽和花蕾的分泌物以及植物伤口的分泌物来生产蜂蜜。这些材料具有高抗生素活性，因为它们具有保护脆弱生长或受伤的植物组织免受微生物和动物攻击的天然功能。蜜蜂用蜂蜜给蜂巢消毒，保护蜂巢不受外来入侵者和感染，并密封蜂巢的裂缝。因此，人类自古以来就将芦荟用于医学目的。现代研究表明，芦荟的一个有价值的特性是其免疫刺激活性，现在广泛用于预防医学以增强免疫系统。此外，其抗氧化和抗炎特性也被认为有助于其目前在补充和替代医学（CAM）中的应用。作为澳大利亚产甘草药用研究的一部分，我们在袋鼠岛（KI）甘草中发现了两类新的生物活性成分，这是首次发现在甘草中存在。尽管碘化钾目前出口到日本用作CAM，但没有研究确定其化学成分或评价其生物活性。因此，我们的目的是研究KI的含量，并评价其作为CAM的药用特性。来自特定地区的蜂胶，具有明确的植物来源和确定的成分，将评估其抗氧化特性和保护活性，防止暴露于阳光的光源等效紫外线辐射后细胞受损，目的是建立一个明确的蜂胶配方，用于局部使用作为CAM，以预防紫外线诱导的皮肤癌，称为黑色素瘤，这是在澳大利亚流行。这项研究将为目前从KI出口的养蜂产品增加价值，并提供健康益处。

Propolis produced by honeybees is a very complex mixture and its chemical composition varies in relation to its floral source. To produce propolis honey bees collect leaf bud and flowerbud exudates also secretions exuded from wounds in plants. These materials have high antibiotic activity as they have a natural function to protect delicate growing or wounded plant tissue from attack from microorganisms and animals. Honey bees use propolis to sterilize the hive and to protect it against outside intruders and infection and to seal cracks in the hive. Consequently, humans have made use of propolis since ancient time for medicinal purposes. Modern research shows that a valuable property of propolis is its immunostimulant activity, now widely used in preventive medicine to boost the immune system. Furthermore, its antioxidant and anti-inflammatory properties are also believed to contribute to its current use in Complementary and Alternative Medicine (CAM). As part of research into the medicinal use of propolis produced in Australia, we identified two novel classes of biologically active constituents in Kangaroo Island (KI) propolis, which are for the first time identified to occur in propolis. Despite KI propolis being currently exported to Japan for use as CAM there is no study to determine its chemical composition or to evaluate its biological activities. Therefore we aim to research the KI propolis and evaluate its medicinal properties for use as CAM. Propolis from specific regions with defined floral sources and the identified constituents will be evaluated for their antioxidant property and protective activities against cell damaged after exposed to light source equivalent UV radiation of the sunlight with the aim to establish a defined propolis formula for topical use as CAM to prevent UV-induced skin cancers, known as melanoma, which is prevalent in Australia. This research will add value to a beekeeping product currently exported from KI and provide a health benefit.