Pharmacological development of synthetic analogues of cytochrome P450-mediated omega-3 fatty acid epoxides as novel anti-metastatic agents

细胞色素 P450 介导的 omega-3 脂肪酸环氧化物的合成类似物作为新型抗转移剂的药理学开发

• 批准号: nhmrc : 1031686
• 负责人: A/Pr Colin Duke
• 金额: $ 57.69万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacological-development-synthetic-metastatic-agents/110818
• 关键词: Pharmacological; development; synthetic; analogues; cytochrome

Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread, or metastasis. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth and migration of tumour cells. We have prepared derivatives of these ?-3 epoxides that retain anti-cancer properties in cells. In this project we will develop analogues of these ?-3 epoxides that are suitable for in vivo testing in animal models of breast cancer metastasis as a new class of potential anti-metastatic drugs.

饮食中的？-3和？-6脂肪酸分别降低和增加癌症扩散或转移的风险。我们发现？-3脂肪酸环氧化物代谢产物抑制肿瘤细胞的生长和迁移。我们已经制备了这些？-3环氧化物的衍生物，它们在细胞中保留了抗癌特性。在这个项目中，我们将开发这些？-3环氧化物的类似物，它们适合于乳腺癌转移动物模型的体内试验，作为一类新的潜在的抗转移药物。