Role of Flavonoids from Phytomedicines in Herb-Drug Interactions Mediated by P-glycoprotein

癌症患者使用草药圣约翰草和银杏叶来缓解与其病情相关的精神障碍症状。这些草药中的黄酮类成分与抗癌治疗之间相互作用的可能性将被研究。对癌症化疗的耐药性通常是由于药物转运体P-糖蛋白(P-gp)的过度表达所致。研究草药制剂中的黄酮类成分与P-gp的相互作用将在短期内确定黄酮类化合物是否会改变耐药癌症的化疗结果。我们还将研究长期接触草药和富含水果和蔬菜类黄酮的饮食中的类黄酮是否会影响多药耐药性的发展和进展。

The herbal therapeutics St John's wort and Ginkgo biloba are used by cancer patients to alleviate symptoms of psychic disturbances associated with their condition. The possibility of interactions between flavonoid components of these herbs and anticancer treatment will be examined. Resistance to cancer chemotherapy often develops due to overexpression of the drug transporter P-glycoprotein (P-gp). Investigation of the interaction of the flavonoid components of herbal preparations and P-gp will establish whether the flavonoids alter the outcome of chemotherapy in resistant cancers in the short term. We will also examine whether exposure to flavonoids in herbal medicines and diets rich in flavonoids from fruit and vegetables affects development and progress of multidrug resistance over the long term.