Role of Flavonoids from Phytomedicines in Herb-Drug Interactions Mediated by P-glycoprotein

植物药中黄酮类化合物在 P-糖蛋白介导的草药-药物相互作用中的作用

• 批准号: nhmrc : 211167
• 负责人: A/Pr Colin Duke
• 金额: $ 14.07万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-flavonoids-phytomedicines-p-glycoprotein/81648
• 关键词: Role; Flavonoids; Phytomedicines; Herb; Drug

The herbal therapeutics St John's wort and Ginkgo biloba are used by cancer patients to alleviate symptoms of psychic disturbances associated with their condition. The possibility of interactions between flavonoid components of these herbs and anticancer treatment will be examined. Resistance to cancer chemotherapy often develops due to overexpression of the drug transporter P-glycoprotein (P-gp). Investigation of the interaction of the flavonoid components of herbal preparations and P-gp will establish whether the flavonoids alter the outcome of chemotherapy in resistant cancers in the short term. We will also examine whether exposure to flavonoids in herbal medicines and diets rich in flavonoids from fruit and vegetables affects development and progress of multidrug resistance over the long term.

草药治疗圣约翰草和银杏叶被癌症患者用来减轻与他们的病情相关的精神障碍症状。这些草药的类黄酮成分和抗癌治疗之间的相互作用的可能性将被检查。对癌症化疗的耐药性通常是由于药物转运蛋白P-糖蛋白（P-gp）的过度表达而产生的。研究草药制剂中的类黄酮成分与P-gp的相互作用将确定类黄酮是否会在短期内改变耐药癌症的化疗结果。我们还将研究暴露于草药中的黄酮类化合物和富含水果和蔬菜中黄酮类化合物的饮食是否会长期影响多药耐药性的发展和进展。