Completion of the MASTER Anaesthesia Trial

完成 MASTER 麻醉试验

• 批准号: nhmrc : 110283
• 负责人: Prof Paul Myles
• 金额: $ 14.18万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/completion-master-anaesthesia-trial/99694
• 关键词: Completion; MASTER; Anaesthesia; Trial

The MASTER Anaesthesia Trial (or Mulcentre Australian Study of Epidural Anaesthesia) is a large clinical experiment designed to determine whether using epidural techniques to control pain during and after surgery results in fewer complications after major surgery. The Trial involves a comparison of epidural methods, in which some of the anaesthetic and pain-killing drugs are injected into the space in the spinal column surrounding the sac that encloses the spinal cord, with conventional methods, where the drugs are injected into a vein or muscle. Both approaches are well accepted in clinical practice, but it remains uncertain whether one is superior to the other. At present, nineteen hospitals in Australia, Hong Kong and Malaysia are contributing patients to the project, with others in New Zealand and Asia expected to join soon. If one method of anaesthesia and pain control is found to be significantly better than the other, in terms of avoiding complications, this would have obvious benefits to patients, but would also reduce lengths of stay in hospital and improve efficiency within the health system.

MASTER麻醉试验（或Mulcentre澳大利亚硬膜外麻醉研究）是一项大型临床实验，旨在确定使用硬膜外技术控制术中和术后疼痛是否会减少大手术后的并发症。该试验涉及硬膜外方法的比较，其中一些麻醉和止痛药物被注射到包围脊髓的囊周围的脊柱空间中，与传统方法相比，药物被注射到静脉或肌肉中。这两种方法在临床实践中都被广泛接受，但仍不确定其中一种是否上级另一种。目前，澳大利亚、香港和马来西亚的19家医院正在为该项目提供病人，新西兰和亚洲的其他医院预计很快也将加入。如果发现一种麻醉和疼痛控制方法在避免并发症方面明显优于另一种方法，这将对患者产生明显的好处，而且还将缩短住院时间，提高卫生系统的效率。