Programmed assembly of protocellular materials

原细胞材料的程序化组装

基本信息

  • 批准号:
    EP/T01508X/1
  • 负责人:
  • 金额:
    $ 49.97万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2020
  • 资助国家:
    英国
  • 起止时间:
    2020 至 无数据
  • 项目状态:
    已结题

项目摘要

Life is an expression of molecular chemistry. We know that living cells and tissues are an assembly of molecules that are reacting and interacting with each other. However, we also know that a molecule is not alive and that a chemical reaction is not alive. So why is it that cells and tissues are alive?With this big scientific question in mind, in recent years, researchers in the field of synthetic biology are trying to fill this gap between life sciences and physical sciences by making the first steps towards the bottom-up development of synthetic cell-like entities, called protocells. They showed that protocells can be built from unanimated molecules and materials such as phospholipids, polymers or even inorganic nanoparticles, and can be chemically programmed to mimic basic functions of living cells such as spontaneous growth and division, phagocytosis, or gene-directed protein synthesis. While many research teams are currently focusing on increasing the levels of biofunctionality and autonomy by advancing the protocells biochemical complexity, Dr Gobbo's research aims to pioneer a new research frontier by starting to spatially organise protocells into protocellular materials (or prototissues) that are stable in water and are capable of emulating living tissues. To achieve this ambitious objective, Dr Gobbo is bringing together in an original and synergistic manner key aspects of synthetic and materials chemistry in combination with synthetic biology. More specifically, his proposed work aims to tackle the following exciting challenges of protocellular materials design and synthetic construction: 1) the development of methodologies for the assembly of protocellular materials; 2) the development of communication pathways within protocellular materials; and 3) the applications of protocellular materials in tissue-engineering and synthetic biology.Achieving forms of fully functional, adaptive and autonomous protocellular materials endowed with a programmable rudimentary form of internalised metabolism would represent an unprecedented scientific achievement. Furthermore, the synthesis of such a form of "active matter" will substantially help bridge the gap between physical and biological sciences, and have profound technological, philosophical, and socioeconomic implications.
生命是分子化学的表现。我们知道,活细胞和活组织是分子的集合体,它们相互反应和相互作用。然而,我们也知道分子不是活的,化学反应也不是活的。那么为什么细胞和组织是活的呢?考虑到这个重大的科学问题,近年来,合成生物学领域的研究人员正试图填补生命科学和物理科学之间的这一空白,他们朝着自下而上开发合成细胞样实体(称为原始细胞)迈出了第一步。他们表明,原始细胞可以由非活性分子和材料(如磷脂,聚合物甚至无机纳米颗粒)构建,并且可以通过化学编程来模拟活细胞的基本功能,如自发生长和分裂,吞噬作用或基因指导的蛋白质合成。虽然许多研究团队目前正专注于通过推进原始细胞的生化复杂性来提高生物功能和自主性水平,但Gobbo博士的研究旨在通过开始将原始细胞在空间上组织成原始细胞材料(或原始组织)来开拓新的研究前沿,这些材料在水中稳定,能够模拟活组织。为了实现这一雄心勃勃的目标,Gobbo博士正在以原创和协同的方式将合成和材料化学的关键方面与合成生物学结合起来。更具体地说,他提出的工作旨在解决原细胞材料设计和合成构建的以下令人兴奋的挑战:1)开发原细胞材料组装的方法; 2)开发原细胞材料内的通讯途径; 3)原细胞材料在组织工程和合成生物学中的应用。实现功能齐全,自适应和自主的原细胞材料被赋予了可编程的内在代谢的基本形式,这将是一项前所未有的科学成就。此外,这种形式的“活性物质”的合成将大大有助于弥合物理科学和生物科学之间的差距,并具有深远的技术,哲学和社会经济影响。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Automated analysis of soft material microindentation.
  • DOI:
    10.1039/d2sm00857b
  • 发表时间:
    2022-10
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Henry E. Symons;Agostino Galanti;Joseph C Surmon;R. Trask;Sébastien Rochat;P. Gobbo
  • 通讯作者:
    Henry E. Symons;Agostino Galanti;Joseph C Surmon;R. Trask;Sébastien Rochat;P. Gobbo
Colloidosomes as a Protocell Model: Engineering Life-Like Behaviour through Organic Chemistry
胶体体作为原始细胞模型:通过有机化学设计类生命行为
Programmed assembly of bespoke prototissues on a microfluidic platform.
  • DOI:
    10.1039/d1lc00602a
  • 发表时间:
    2021-11
  • 期刊:
  • 影响因子:
    6.1
  • 作者:
    Kaitlyn Ramsay;Jae Levy;P. Gobbo;K. Elvira
  • 通讯作者:
    Kaitlyn Ramsay;Jae Levy;P. Gobbo;K. Elvira
Front Cover: Colloidosomes as a Protocell Model: Engineering Life-Like Behaviour through Organic Chemistry (Eur. J. Org. Chem. 6/2023)
封面:作为原始细胞模型的胶体体:通过有机化学工程拟生命行为(Eur. J. Org. Chem. 6/2023)
Bioinspired Networks of Communicating Synthetic Protocells.
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Pierangelo Gobbo其他文献

Pierangelo Gobbo的其他文献

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