CYRO-ROP PARTICIPATING CENTER

CYRO-ROP 参与中心

• 批准号: 3551722
• 负责人: ALBERT BIGLAN
• 金额: $ 5.93万
• 依托单位: MAGEE-WOMEN'S HOSPITAL OF UPMC
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1989-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3551722
• 关键词: blindness; case history; cooperative study; cryotherapy; disease /disorder prevention /control; human subject; human therapy evaluation; premature infant human; retina disorder

This is an application to become one of the cooperating study centers in the Cryotherapy of Retinopathy of Prematurity Study. The CRYO-ROP Study consists of essentially two research components: (1) a clinical trial of the safety and efficacy of cryotherapy in reducing blindness in eyes with severe, high-risk, ROP; and (2) a study of the natural history (in accord with the international classification of ROP) of retinopathy of prematurity in very low birth weight infants (less than 1,251 g). In this proposal, we document the ability of our group of ophthalmologists and neonatologists to enroll, each year, 136 very low birth weight infants who have survived for a least 28 days in the natural history study. We anticipate that 10 of these infants will also develop retinopathy of prematurity severe enough to become eligible for enrollment to the clinical trial, and that an additional 3 patients will be referred to our center for enrollment in the trial from other nurseries in the area (based on referral history over past 5 years).

这是一份申请书，申请成为 早产儿视网膜病变冷冻治疗研究 CRYO-ROP研究 主要包括两个研究部分：（1）临床试验， 冷冻治疗在致盲中的安全性和有效性 重度、高危、ROP;（2）自然史研究（雅阁 与ROP的国际分类）的早产儿视网膜病变 极低出生体重婴儿（小于1，251 g）。 在本提案中，我们记录了我们眼科医生团队的能力 和产科医生每年招募136名极低出生体重婴儿， 在自然史研究中存活了至少28天的动物。 我们 预计其中10名婴儿也会出现视网膜病变， 早产严重到足以有资格入组临床 试验，另外3名患者将被转介到我们的中心， 从该地区的其他托儿所入组试验（基于转诊 过去5年的历史）。