OPTIC NEURITIS TREATMENT TRIAL COOPERATING CLINIC

视神经炎治疗试验合作诊所

• 批准号: 3552071
• 负责人: EDWARD G BUCKLEY
• 金额: $ 9.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3552071
• 关键词: case history; cooperative study; drug administration routes; human subject; human therapy evaluation; injection /infusion; methylprednisolone; optic neuritis; prednisone

This is an application to become one of the cooperating clinics in the optic neuritis treatment trial. The ONTT consist of essentially two research components; (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural history of optic neuritis. In this proposal we document our patient recruitment potential. Our group of ophthalmologists and neurologists saw 130 patients with optic neuritis, with 26 patients meeting the listed study criteria within a 12 month period. In addition we provide data from one neuro-ophthalmologist in our referral area, willing to refer patients for the study, who has seen a total eight patients with optic neuritis meeting the study criteria within a 12 month period.

这是一个申请成为合作诊所之一， 视神经炎治疗试验 ONT包括 基本上有两个研究组成部分：（1）临床试验， 口服泼尼松与静脉注射甲泼尼龙治疗原发性高血压疗效比较 减少视神经损伤患者的残余视神经损伤 视神经炎;（2）视神经炎自然史的研究。 在本提案中，我们记录了我们的患者招募潜力。 我们的眼科医生和神经科医生小组看了130个病人， 患有视神经炎，26名患者符合所列研究 标准在12个月内。 此外，我们还提供数据 来自我们转诊区域的一位神经眼科医生， 为这项研究推荐病人，他总共看过8个病人， 视神经炎在12个月内符合研究标准 期