CRYO-ROP PARTICIPATING CENTER

这是一份成为中国合作学习中心之一的申请 冷冻疗法治疗早产儿视网膜病变的研究Cyro-ROP研究 主要由两个研究部分组成：(1)临床试验 冷冻治疗青光眼的安全性和有效性 严重、高风险、ROP；和(2)自然历史研究(符合 早产儿视网膜病变的国际分级) 极低出生体重儿(小于1,250克)。 在这份提案中，我们记录了我们的眼科医生小组的能力 和新生儿科医生招收，每年132名极低出生体重儿 在自然历史研究中存活了至少28天。我们 预计其中8到10名婴儿也会患上视网膜病变 早产儿严重到有资格参加 临床试验，并将转介另外3至5名患者 到我们的书房登记参加那次试验。

This is an application to become one of the cooperating study centers in the Cryotherapy for Retinopathy of Prematurity Study. The CYRO-ROP Study consists of essentially two research components: (1) A clinical trial of the safety and efficacy of cryotherapy in reducing blindness in eyes with severe, high, risk, ROP; and (2) a study of the natural history (in accord with the international classification of ROP) of retinopathy of prematurity in very low birth weight infants (less than 1,250 grams). In this proposal, we document the ability of our group of ophthalmologists and neonatologists to enroll, each year 132 very low birth weight infants who have survived at least 28 days in the natural history study. We anticipate that eight to ten of these infants will also develop retinopathy of prematurity severe enough to become eligible for enrollment to the clinical trial, and an additional three to five patients will be referred to our study for enrollment to that trial.