NHLBI GROWTH AND HEALTH STUDY EXTENSION

NHLBI 成长和健康研究扩展

• 批准号: 3553544
• 负责人: Z I SABRY
• 金额: $ 59.89万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553544
• 关键词: African American; adolescence (12-20); blood chemistry; blood lipid; blood pressure; body composition; body physical activity; cardiovascular disorder; cardiovascular disorder epidemiology; case history; caucasian American; diet; disease /disorder proneness /risk; family; female; health behavior; human puberty; human subject; longitudinal human study; nutrition related tag; obesity; racial /ethnic difference; self concept; socioeconomics; stress

The objective of this longitudinal study is to follow a cohort of 2379 black and white girls, age 9 and 10 years, and their parents, through pubescence to: (a) investigate whether, and to what extent, the race difference in the development of obesity in adolescent females can be explained by differences in dietary habits, patterns of physical activity, socioeconomic status, psychosocial factors, age and sexual maturation; and (b) determine whether, and to what degree, differences in the development of obesity are associated with differences in other coronary vascular disease risk factors, such as blood pressure, blood lipids/lipoproteins and apolipoproteins. The study has been conducted for 5 years and it is proposed to extend the follow-up by five more years to fully explicate the racial divergence in obesity during puberty and its effect on the major CVD risk factors. Specifically, the study aims to assess: (1) anthropometric parameters reflecting obesity and distribution of body fat; (2) changes in dietary intake and physical activity; (3) psychosocial measures of self- esteem, stress and health perceptions; (4) blood pressure, lipid profiles, and fasting glucose and insulin; (5) relevant health indicators associated with adolescence and familial influences on all these parameters. The strength of the study in retaining about 90% of the cohort will undoubtedly contribute to its continued success in meeting its overall objectives and specific aims. The experience gained in the past five years in developing and implementing a detailed protocol and training a cadre of qualified examiners and interviewers will ensure the high quality of the data. The study itself will yield important scientific information to help elucidate the underlying mechanism of the higher incidence of obesity and hypertension in black adolescent girls, help identify the factors associated with the higher CVD mortality in black women and lead to effective interventions.

这项纵向研究的目的是追踪 2379 名参与者 9 岁和 10 岁的黑人和白人女孩及其父母，通过 青春期：（a）调查种族是否以及在何种程度上 青春期女性肥胖发展的差异可能是 可以通过饮食习惯、体力活动模式的差异来解释， 社会经济状况、社会心理因素、年龄和性成熟程度；和 (b) 确定发育是否存在差异以及差异程度如何 肥胖的发生与其他冠状血管的差异有关 疾病危险因素，例如血压、血脂/脂蛋白和 载脂蛋白。 该研究已进行了5年， 建议将后续行动再延长五年，以充分阐明 青春期肥胖的种族差异及其对主要心血管疾病的影响 风险因素。 具体来说，该研究旨在评估：（1）人体测量 反映肥胖和体脂肪分布的参数； (2) 变化 饮食摄入量和体力活动； (3)自我心理社会测量 尊重、压力和健康观念； (4) 血压、血脂、 以及空腹血糖和胰岛素； (5)相关健康指标 青春期和家庭对所有这些参数的影响。 这 该研究在保留大约 90% 的队列方面的实力无疑将 有助于其持续成功地实现其总体目标和 具体目标。 过去五年的发展经验 并实施详细的协议并培训合格的干部 审查员和访谈员将确保数据的高质量。 这 研究本身将产生重要的科学信息来帮助阐明 肥胖发生率较高的根本机制 黑人青春期女孩高血压，帮助确定因素 与黑人女性较高的 CVD 死亡率相关，并导致 有效的干预措施。