NHLBI GROWTH AND HEALTH STUDY EXTENSION

这项纵向研究的目的是跟踪2379名队列 9岁和10岁的黑人和白色女孩及其父母， （a）调查是否以及在何种程度上， 青春期女性肥胖症发展的差异可能是 这可以用饮食习惯，体力活动模式， 社会经济状况、心理社会因素、年龄和性成熟;以及 (b)确定是否以及在何种程度上， 肥胖与其他冠状动脉血管疾病的差异有关。 疾病风险因素，如血压、血脂/脂蛋白和 载脂蛋白 这项研究已经进行了5年， 建议将后续行动再延长五年， 青春期肥胖的种族差异及其对主要心血管疾病的影响 危险因素 具体而言，该研究旨在评估：（1）人体测量 反映肥胖和体脂分布的参数;（2） 饮食摄入和体力活动;（3）自我的心理社会措施， 自尊，压力和健康观念;（4）血压，血脂谱， 空腹血糖和胰岛素;（5）相关健康指标 青春期和家庭对这些参数的影响。 的 这项研究在保留约90%的队列方面的优势无疑将 有助于继续成功地实现其总体目标， 具体目标。 过去五年在发展中国家 执行详细的协议，培训合格的干部， 审查员和访谈员将确保数据的高质量。 的 研究本身将产生重要的科学信息， 肥胖症发病率较高的潜在机制， 黑人少女的高血压，帮助确定因素 与黑人女性较高的心血管疾病死亡率相关， 有效干预。

The objective of this longitudinal study is to follow a cohort of 2379 black and white girls, age 9 and 10 years, and their parents, through pubescence to: (a) investigate whether, and to what extent, the race difference in the development of obesity in adolescent females can be explained by differences in dietary habits, patterns of physical activity, socioeconomic status, psychosocial factors, age and sexual maturation; and (b) determine whether, and to what degree, differences in the development of obesity are associated with differences in other coronary vascular disease risk factors, such as blood pressure, blood lipids/lipoproteins and apolipoproteins. The study has been conducted for 5 years and it is proposed to extend the follow-up by five more years to fully explicate the racial divergence in obesity during puberty and its effect on the major CVD risk factors. Specifically, the study aims to assess: (1) anthropometric parameters reflecting obesity and distribution of body fat; (2) changes in dietary intake and physical activity; (3) psychosocial measures of self- esteem, stress and health perceptions; (4) blood pressure, lipid profiles, and fasting glucose and insulin; (5) relevant health indicators associated with adolescence and familial influences on all these parameters. The strength of the study in retaining about 90% of the cohort will undoubtedly contribute to its continued success in meeting its overall objectives and specific aims. The experience gained in the past five years in developing and implementing a detailed protocol and training a cadre of qualified examiners and interviewers will ensure the high quality of the data. The study itself will yield important scientific information to help elucidate the underlying mechanism of the higher incidence of obesity and hypertension in black adolescent girls, help identify the factors associated with the higher CVD mortality in black women and lead to effective interventions.