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PEPR - A centre for Pulse Electron Paramagnetic Resonance spectroscopy at Imperial College

PEPR - 帝国理工学院脉冲电子顺磁共振波谱中心

基本信息

批准号：
EP/T031425/1
负责人：
Maxie Roessler
金额：
$ 291.54万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FT031425%2F1
关键词：
PEPR centre Pulse Electron Paramagnetic

项目摘要

Unpaired electrons play vital roles in e.g. respiration and photosynthesis, are associated with human diseases including cancer and Alzheimer's disease and are at the basis of the modern computer and many industrially used catalysts. We propose to set up a new research facility at Imperial College London which employs a powerful technique called ulse Electron Paramagnetic Resonance (EPR) spectroscopy, to identify and characterise such unpaired electrons (free radicals) and gain detailed insight into the structure and dynamics of paramagnetic compounds. The facility (PEPR) will therefore contribute to solving grand, societal challenges such as healthy aging, sustainable energy generation and storage, greener and more effective catalytic solutions for chemical manufacturing and developing a new generation of electronic devices. PEPR will encompass state-of-the-art pulse EPR instrumentation and in partnership with University College London we will develop new instrumentation and methodology to push the boundaries of what is possible with EPR today and widen the applications of this already extremely versatile technique. We will do this by combining EPR spectroscopy with electrochemistry, a powerful method for investigating oxidation-reduction processes that often lie at the heart of systems with unpaired electrons and by enabling pulse EPR investigations of paramagnetic compounds that cannot be accumulated in sufficiently large quantities to be studied with current commercially-available instrumentation. PEPR will therefore bring new capabilities to the UK, build on the existing research strengths and infrastructure at Imperial College and engage new academic users and research centres across London, regionally and UK-wide. The research facilitated by PEPR will have an immediate impact on UK science, with academic beneficiaries in a diverse range of research disciplines, and a significant people-pipeline through the many affiliated PhD students and PDRAs. Moreover, the facility's location at Imperial College's newly-established and growing innovation campus at White City provides a unique opportunity to encourage academia and industry to collaborate more closely on common, global challenges. Access to the wider community will be provided through outreach events such as the Great Exhibition Road Festival and the Imperial Lates, as well as by including the facility into the tours that are already taking place regularly in the Molecular Sciences Research Hub where PEPR will be located.

不成对电子在例如呼吸和光合作用中起着至关重要的作用，与包括癌症和阿尔茨海默病在内的人类疾病有关，并且是现代计算机和许多工业上使用的催化剂的基础。我们建议在伦敦帝国理工学院建立一个新的研究设施，采用一种强大的技术，称为脉冲电子顺磁共振（EPR）光谱，以识别和识别这样的未成对电子（自由基），并获得详细的洞察顺磁性化合物的结构和动力学。因此，该设施（PEPR）将有助于解决重大的社会挑战，例如健康老龄化，可持续能源生产和储存，更环保，更有效的化学制造催化解决方案以及开发新一代电子设备。PEPR将包括最先进的脉冲EPR仪器，并与伦敦大学学院合作，我们将开发新的仪器和方法，以推动当今EPR的可能性，并扩大这种已经非常通用的技术的应用。我们将通过将EPR光谱与电化学相结合来做到这一点，电化学是一种强大的方法，用于研究氧化还原过程，该过程通常位于具有未成对电子的系统的核心，并且通过使顺磁性化合物的脉冲EPR研究能够积累足够大的量来研究当前的商业仪器。因此，PEPR将为英国带来新的能力，建立在帝国理工学院现有的研究优势和基础设施的基础上，并在伦敦，区域和英国范围内吸引新的学术用户和研究中心。由PEPR促进的研究将对英国科学产生直接影响，在各种研究学科中具有学术受益者，并通过许多附属博士生和PDRA提供重要的人才管道。此外，该设施位于帝国理工学院在白城新建立和不断发展的创新校园，为鼓励学术界和工业界就共同的全球挑战进行更密切的合作提供了一个独特的机会。通过大展览之路节和帝国晚礼服等外联活动，以及将该设施纳入已在PEPR所在的分子科学研究中心定期举行的图尔斯之旅，将提供更广泛的社区。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bio-Electrocatalytic Conversion of Food Waste to Ethylene via Succinic Acid as the Central Intermediate

以琥珀酸为中心中间体生物电催化厨余转化乙烯

DOI：
10.1021/acscatal.2c0268913360
发表时间：
2022
期刊：
ACS CATALYSIS
影响因子：
12.9
作者：
Pichler Christian M.
通讯作者：
Pichler Christian M.

Bio-Electrocatalytic Conversion of Food Waste to Ethylene via Succinic Acid as the Central Intermediate.

DOI：
10.1021/acscatal.2c02689
发表时间：
2022-11-04
期刊：
ACS CATALYSIS
影响因子：
12.9
作者：
Pichler, Christian M.;Bhattacharjee, Subhajit;Lam, Erwin;Su, Lin;Collauto, Alberto;Roessler, Maxie M.;Cobb, Samuel J.;Badiani, Vivek M.;Rahaman, Motiar;Reisner, Erwin
通讯作者：
Reisner, Erwin

Squarephaneic Tetraanhydride: A Conjugated Square-Shaped Cyclophane for the Synthesis of Porous Organic Materials**

方烷四酐：用于合成多孔有机材料的共轭方形环烷**

DOI：
10.1002/ange.202212623
发表时间：
2022
期刊：
Angewandte Chemie
影响因子：
0
作者：
Eder S
通讯作者：
Eder S

Understanding the effects of targeted modifications on the 1 : 2 Choline And GEranate structure.

了解靶向修饰对 1:2 胆碱和 GEranate 结构的影响。

DOI：
10.1039/d3cp05271k
发表时间：
2024
期刊：
PCCP
影响因子：
0
作者：
Dobre A
通讯作者：
Dobre A

A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I.

DOI：
10.1016/j.jbc.2021.100474
发表时间：
2021-01
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Hameedi MA;Grba DN;Richardson KH;Jones AJY;Song W;Roessler MM;Wright JJ;Hirst J
通讯作者：
Hirst J