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MOLECULAR CLONING OF PYRUVATE DEHYDROGENASE GENE

MOLECULAR CLONING OF PYRUVATE DEHYDROGENASE GENE
丙酮酸脱氢酶基因的分子克隆
批准号：
3821233
负责人：
B J SONG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3821233
关键词：
alcoholic beverage consumption alcoholic hepatitis alcoholism /alcohol abuse butanols diol genetic mapping genetic markers liver cirrhosis liver metabolism liver toxic disorder molecular cloning molecular pathology pyruvate dehydrogenase

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中文摘要
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英文摘要
Recent studies from our laboratory indicate that 2,3-butanediol, one of two unusual metabolites found in human alcoholic blood, is predominantly associated with human subjects who suffer alcoholic hepatitis or alcoholic cirrhosis (Casazza et al., Alcohol and Alcoholism, Suppl. 1: 607-609, 1987). The mechanism of the formation of 2,3-butanediol via pyruvate dehydrogenase was initially proposed by Veech et al. (Curr. Top. Cell. Regul 18: 151- 179, 1981). Based on the proposal, we have just started a project to clone pyruvate dehydrogenase (PDH) gene and to characterized its gene in light of developing a specific probe for a genetic marker for human alcoholism.
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REGULATION OF THIAMINE-DEPENDENT ENZYMES INVOLVED IN GLUCOSE METABOLISM
RADIOIMMUNOASSAY OF CYTOCHROMES P-450 USING MONOCLONAL ANTIBODIES
REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
MOLECULAR CLONING OF PYRUVATE DEHYDROGENASE GENE
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