REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素 P450 基因的调控
基本信息
- 批准号:3789488
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
As a continuous ongoing project, the molecular regulatory mechanism of
P450IIE was further investigated. We have previously identified and
determined the structures of the ethanol-inducible cytochrome P450
(P450IIE1) of both rat and human. We have also demonstrated three
distinct types of regulation of P450IIE1 in rat. The three types of
upregulation of P450IIE appeared to be present in liver, lung and kidney
tissues. The molecular mechanism of P450IIE1 regulation by other exogenous
regulators and during pregnancy were further investigated.
Pretranlational activation of P450IIE1 during ketosis induced by a fat
diet where the elevation of its mRNA level correlated with the levels of
acetoacetate and beta-hydroxybutyrate but not with that of acetone which
activates P450IIE1 without elevating its mRNA level. Specific
translational induction of P450IIE1 by isoniazid and N-heterocyclic
compounds such as pyrazine was demonstrated. Pretranslational reduction
of P450IIE during pregnancy and rapid reversal upon parturition were
studied. The reduction of P450IIE1 during late-term pregnancy indicates
a negative hormonal control mechanism which we are currently
investigating. In contrast, pentoxyresorufin O-depentylase (associated
with P450IIB1/B2) was pretranslationally activated by the same inducer,
pyridine. A rapid and sensitive assay for P450IIE1 is being developed for
the detection of P450IIE1 expressed in human lymphocytes.
作为一个持续进行的项目,
P450 IIE的进一步研究。我们之前已经确认,
确定了乙醇诱导的细胞色素P450的结构
(P450 IIE 1)的表达。 我们还展示了三个
P450 IIE 1在大鼠中的不同调节类型。 的三类
P450 IIE在肝、肺和肾中表达上调
组织中P450 IIE 1基因在其他外源性基因调控中的分子机制
监管机构和怀孕期间进行了进一步调查。
P450 IIE 1在脂肪酮病中的转录前激活
饮食中其mRNA水平的升高与
乙酰乙酸酯和β-羟基丁酸酯,但不与丙酮反应,
激活P450 IIE 1而不提高其mRNA水平。具体
异烟肼和N-杂环对P450 IIE 1翻译诱导作用
例如吡嗪的化合物。 翻译前还原
P450 IIE在妊娠期的表达和分娩后的快速逆转,
研究了 妊娠晚期P450 IIE 1的降低提示
一种消极的荷尔蒙控制机制,
调查 与此相反,戊氧基试卤灵O-脱戊基酶(相关
与P450 IIB 1/B2)被相同的诱导剂预先激活,
吡啶。 目前正在开发一种快速、灵敏的P450 IIE 1检测方法,
检测人淋巴细胞中P450 IIE 1的表达。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('B J SONG', 18)}}的其他基金
REGULATION OF THIAMINE-DEPENDENT ENZYMES INVOLVED IN GLUCOSE METABOLISM
参与葡萄糖代谢的硫胺依赖性酶的调节
- 批准号:
3745202 - 财政年份:
- 资助金额:
-- - 项目类别:
RADIOIMMUNOASSAY OF CYTOCHROMES P-450 USING MONOCLONAL ANTIBODIES
使用单克隆抗体对细胞色素 P-450 进行放射免疫测定
- 批准号:
4692384 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素 P450 基因的调控
- 批准号:
3801921 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF THIAMINE DEPENDENT ENZYMES INVOLVED IN GLUCOSE METABOLISM
参与葡萄糖代谢的硫胺素依赖性酶的调节
- 批准号:
5200218 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素 P450 基因的调控
- 批准号:
3745201 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素 P450 基因的调控
- 批准号:
3808628 - 财政年份:
- 资助金额:
-- - 项目类别:
STRUCTURE AND REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素P450基因的结构和调控
- 批准号:
3821232 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF ETHANOL-INDUCIBLE CYTOCHROME P450 GENE
乙醇诱导细胞色素 P450 基因的调控
- 批准号:
3767543 - 财政年份:
- 资助金额:
-- - 项目类别:
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