MECHANISMS OF ABNORMAL AUTOMATICITY IN CARDIAC PREPARATIONS
MECHANISMS OF ABNORMAL AUTOMATICITY IN CARDIAC PREPARATIONS
批准号:
3823195
负责人:
M C CAPOGROSSI
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
虽然静息的哺乳动物心室肌通常不表现出
起搏器样活动,在某些条件下自发局部
肌浆网(SR)释放Ca 2+导致
肌浆[Ca 2 +](Ca-i),其引起微小的内向电流,
在膜电位的振荡中。 在正常的静息膜上
心肌细胞的电位不足以引起动作
潜力 然而,当自发SR Ca 2+释放同时发生时,
在多于一个基因座处,即当这些基因座“同步化”时,
所产生的肌膜去极化增加到
有时足以产生自发动作电位,
收缩。 因此,多个区域的局部自发性Ca 2+释放
在心室心肌细胞内,如果“同步”是一种机制,
这些细胞中的异常自律性,可以产生“心脏跳动,
反面. "
英文摘要
While resting mammalian ventricular myocardium does not usually exhibit
pacemaker like activity, under certain conditions spontaneous localized
release of Ca2+ from sarcoplasmic reticulum (SR) results in an increase in
myoplasmic [Ca2+] (Ca-i) which causes miniature inward currents resulting
in oscillations of membrane potential. At the normal resting membrane
potential in cardiac myocytes this is insufficient to induce an action
potential. However, when spontaneous SR Ca2+ release occurs simultaneously
at more than a single locus, i.e. when these loci are "synchronized," the
resultant sarcolemmal depolarization is augmented to levels that are
sometimes sufficient to produce a spontaneous action potential and
contraction. Thus, multiple areas of localized spontaneous Ca2+ release
within ventricular cardiac cells, if "synchronized" is a mechanism for
abnormal automaticity in these cells and can produce a "heart beat in
reverse."
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EFFECT OF ALPHA-ADRENERGIC STIMULATION ON ISOLATED VENTRICULAR MYOCYTES
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批准号:3817601
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
GENE THERAPY OF CORONARY ARTERY DISEASE
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批准号:3745552
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
MECHANISMS OF ABNORMAL AUTOMATICITY IN CARDIAC PREPARATIONS
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批准号:3821461
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
GENE THERAPY TO INDUCE THERAPEUTIC ANGIOGENESIS
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批准号:2565760
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
EXCITATION-CONTRACTION IN ISOLATED CARDIAC CELLS
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批准号:3821449
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
EFFECT OF ALPHA-ADRENERGIC STIMULATION ON ISOLATED VENTRICULAR MYOCYTES
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批准号:3813644
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
MECHANISM FOR SIGNAL TRANSDUCTION OF SHEAR STRESS FORCES IN ENDOTHELIAL CELLS
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批准号:3789792
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
PATHOPHYSIOLOGIC EFFECTS OF SPONTANEOUS CA2+ RELEASE IN THE HEART
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批准号:3821463
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
GENE THERAPY OF CORONARY ARTERY DISEASE
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批准号:3767877
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
MECHANISM FOR SIGNAL TRANSDUCTION OF SHEAR STRESS FORCES IN ENDOTHELIAL CELLS
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批准号:3767792
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
EXCITATION-CONTRACTION IN ISOLATED CARDIAC CELLS
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批准号:4687923
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
GENE THERAPY OF CORONARY ARTERY DISEASE
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批准号:5200352
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
GENE THERAPY TO INDUCE THERAPEUTIC ANGIOGENESIS
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批准号:6160494
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
PATHOPHYSIOLOGIC EFFECTS OF SPONTANEOUS CA2+ RELEASE IN THE HEART
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批准号:3817598
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
EXCITATION-CONTRACTION IN ISOLATED CARDIAC CELLS
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批准号:3823182
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M C CAPOGROSSI
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依托单位:
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