REGULATION OF INTERLEUKIN 2 GENE EXPRESSION IN LYMPHOID AND NONLYMPNOLD CELLS

淋巴细胞和非淋巴细胞中白细胞介素 2 基因表达的调节

• 批准号: 3960032
• 负责人: N J HOLBROOK
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3960032
• 关键词: Retroviridae; aging; cytokine; fibroblasts; gene expression; genetic manipulation; genetic regulation; interleukin 2; lymphatic tissue; molecular genetics

This project is focused at understanding the basic control mechanisms responsible for expression of the human interleukin 2 (IL-2) gene. Particular items within this study include (1) expression of the human IL-2 gene in mouse fibroblasts with DNA-mediated transfer; (2) mechanism for the activation of IL-2 expression in MLA 144 cells by a retrovirus insertion in the gene; and (3) role of 3' sequences in controlling IL-2 expression.

这个项目的重点是理解基本的控制机制