AGE ASSOCIATED CHANGES IN VASCULAR PROPERTIES

年龄相关的血管特性变化

• 批准号: 3802240
• 负责人: E LAKATTA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802240
• 关键词: aging; artery; blood pressure; body composition; gender difference; histopathology; human middle age (35-64); human old age (65+); intracardiac volume; myocardium; nuclear magnetic resonance spectroscopy; stroke

As arterial and myocardial changes occur in otherwise healthy older individuals within the Western society they are often referred to as a part of a "normal aging process". However, the arterial stiffness increase (indexed by an increase in arterial pulse wave velocity) and the arterial pressure increase with age are heterogeneous among various populations worldwide and among individuals within a given population. The ultimate goals of this project are to address the issue of how alterations in arterial stiffness affect the myocardium and whether in outcome studies they relate to vascular insufficiency syndromes, e.g., stroke. We have initiated a pilot study in which measurements of cardiac mass (via NMR), filling properties and isovolumic relaxation time (via echo-doppler device), carotid pressure pulse (via applanation tomography) and arterial pulse wave velocity (doppler sonography) are made in men and women who differ with respect to age, arterial pressure, body composition, and physical conditioning status. As expected, preliminary results indicate that with increasing age arterial stiffening leads to an increase in pulse wave velocity. This is associated with an early return of reflected pulse waves from peripheral sites which produce an augmented and late occurring peak of carotid pressure pulse. It is important to note that these arterial changes are, by and large, not detected by routine clinical measures of brachial arterial pressure. Of note, also is that in highly physically conditioned older individuals (>60 yrs of age) the arterial stiffness and reflected wave indices are markedly reduced and do not differ from younger individuals, although the age-associated increase in systolic pressure persists. We have taken the initiative to extend many of these studies to other non-Western populations in which different patterns of arterial pressure of change occurs with aging (in China via a collaborative research contract).

当其他健康的老年人发生动脉和心肌变化时 西方社会中的个人，他们通常被称为 “正常的衰老过程”。然而，动脉僵硬增加 (以动脉脉搏波速度的增加为指标)和动脉 随年龄增加的压力在不同人群中是不同的 在世界范围内和在特定人口内的个人之间。终极的 该项目的目标是解决如何在 动脉僵硬对心肌的影响以及是否在结果研究中 它们与血管功能不全综合症有关，例如中风。我们有 启动了一项初步研究，其中心脏质量的测量(通过核磁共振)， 充盈特性和等容弛豫时间(通过回声多普勒 设备)、颈动脉压力脉搏(通过压平断层扫描)和动脉 脉搏波速度(多普勒超声)是在以下情况下进行的 在年龄、动脉压、身体成分和 体能状态。正如预期的那样，初步结果表明 随着年龄的增长，动脉硬化导致脉搏增加 波速。这与反射脉冲的提前返回有关 来自外围部位的波，产生增强的和晚发生的 颈动脉压力脉搏的峰值。值得注意的是，这些 大体上，常规的临床是无法发现动脉改变的。 测量臂动脉压。值得注意的是，在高度的 身体状况良好的老年人(60岁)动脉 僵硬指数和反射波指数显著降低，没有差别 来自更年轻的个体，尽管与年龄相关的收缩压增加 压力依然存在。我们已经主动延长了其中的许多 对其他非西方人群的研究，其中不同的模式 动脉压随着年龄的增长而发生变化(在中国中通过合作 研究合同)。