AGE ASSOCIATED CHANGES IN VASCULAR PROPERTIES

由于动脉和心肌的变化发生在其他健康的老年人 在西方社会中，他们经常被称为一部分人。 “正常的衰老过程”。 然而，动脉僵硬度增加 （以动脉脉搏波速度的增加为指标）和动脉 压力随年龄增长在不同人群中是不均匀的 在世界范围内和特定人群中的个体之间。 最终 该项目的目标是解决如何改变的问题， 动脉僵硬度影响心肌，是否在结局研究中 它们涉及血管功能不全综合征，例如，中风 我们有 启动了一项试点研究，其中测量心脏质量（通过NMR）， 充盈特性和等容舒张时间（通过回波多普勒 设备）、颈动脉压力脉搏（通过扁平断层扫描）和动脉 脉搏波速度（多普勒超声）是在男性和女性， 年龄、动脉压、身体成分和 身体状况 正如预期的那样，初步结果表明， 随着年龄的增长，动脉硬化导致脉搏增加， 波速 这与反射脉冲的早期返回有关 来自外周部位的波，其产生增强的和迟发的 颈动脉压力脉搏峰值。 值得注意的是，这些 动脉变化大体上不能通过常规临床检查检测到， 测量肱动脉压。 值得注意的是，在高度 身体条件的老年人（>60岁）动脉 刚度和反射波指数显著降低， 尽管与年龄相关的收缩压增加 压力持续存在。 我们已主动延长了其中许多 其他非西方人群的研究，其中不同的模式， 动脉压的变化随着年龄的增长而发生（在中国，通过合作 研究合同）。

As arterial and myocardial changes occur in otherwise healthy older individuals within the Western society they are often referred to as a part of a "normal aging process". However, the arterial stiffness increase (indexed by an increase in arterial pulse wave velocity) and the arterial pressure increase with age are heterogeneous among various populations worldwide and among individuals within a given population. The ultimate goals of this project are to address the issue of how alterations in arterial stiffness affect the myocardium and whether in outcome studies they relate to vascular insufficiency syndromes, e.g., stroke. We have initiated a pilot study in which measurements of cardiac mass (via NMR), filling properties and isovolumic relaxation time (via echo-doppler device), carotid pressure pulse (via applanation tomography) and arterial pulse wave velocity (doppler sonography) are made in men and women who differ with respect to age, arterial pressure, body composition, and physical conditioning status. As expected, preliminary results indicate that with increasing age arterial stiffening leads to an increase in pulse wave velocity. This is associated with an early return of reflected pulse waves from peripheral sites which produce an augmented and late occurring peak of carotid pressure pulse. It is important to note that these arterial changes are, by and large, not detected by routine clinical measures of brachial arterial pressure. Of note, also is that in highly physically conditioned older individuals (>60 yrs of age) the arterial stiffness and reflected wave indices are markedly reduced and do not differ from younger individuals, although the age-associated increase in systolic pressure persists. We have taken the initiative to extend many of these studies to other non-Western populations in which different patterns of arterial pressure of change occurs with aging (in China via a collaborative research contract).