AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

血管硬度特性与年龄相关的变化

• 批准号: 3789790
• 负责人: E LAKATTA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789790
• 关键词: African American; aging; artery; blood pressure; body composition; carotid artery; disease /disorder proneness /risk; exercise; female; gender difference; heart circulation; human middle age (35-64); human old age (65+); human subject; intracardiac volume; male; myocardium; nuclear magnetic resonance spectroscopy; physical fitness; pulse pressure wave; stroke; ultrasound blood flow measurement; vascular resistance

As arterial and myocardial changes occur in otherwise healthy older individuals within the Western society they are often referred to as a part of a "normal aging process." However, the arterial stiffness increase (indexed by an increase in arterial pulse wave velocity) and the arterial pressure increase with age are heterogeneous among various populations worldwide and among individuals within a given population. The ultimate goals of this project are to address the issue of how alterations in arterial stiffness affect the myocardium and whether in outcome studies they relate to vascular insufficiency syndromes, e.g., stroke. We have initiated a pilot study in which measurements of cardiac mass (via NMR), filling properties and isovolumic relaxation time (via Doppler echocardiography), carotid pressure pulse (via applanation tomography) and arterial pulse wave velocity (Doppler sonography) are made in men and women who differ with respect to age, arterial pressure, body composition, and physical conditioning status. As expected, results indicate that with increasing age arterial stiffening leads to an increase in pulse wave velocity. This is associated with an early return of reflected pulse waves from peripheral sites which produce an augmented and late occurring peak of carotid pressure pulse. It is important to note that these arterial changes are, by and large, not detected by routine clinical measures of brachial arterial pressure and are independent of gender, but vary inversely with exercise capacity. Of note, also is that in highly physically conditioned older individuals (>60 yrs of age) the arterial stiffness and reflected wave indices are markedly reduced and do not differ from those of younger individuals, although the age-associated increase in systolic pressure persists. We have taken the initiative to extend many of these studies to Black Americans and to other non-Western populations in which different patterns of arterial pressure change occurs with aging (in China via a research contract).

由于动脉和心肌变化发生在其他健康的老年人身上 在西方社会中，他们通常被称为 “正常衰老过程”的一部分。 然而，动脉僵硬度 增加（以动脉脉搏波速度的增加为索引）和 动脉压随年龄的增加在不同人群之间存在差异 世界各地的人口以及特定人口中的个人之间。 该项目的最终目标是解决如何 动脉硬度的变化会影响心肌，并且是否会影响心肌？ 与血管功能不全综合征相关的结果研究，例如， 中风。 我们已经启动了一项试点研究，其中测量心脏 质量（通过 NMR）、填充特性和等容弛豫时间（通过 多普勒超声心动图），颈动脉压力脉冲（通过压平 断层扫描）和动脉脉搏波速度（多普勒超声检查） 年龄、动脉压、身体状况不同的男性和女性 成分和身体状况。 结果如预期 表明随着年龄的增长，动脉硬化会导致 在脉搏波速度中。 这与提前返回有关 从周围部位反射的脉冲波产生增强和 颈动脉压力脉冲峰值出现较晚。 重要的是要注意 总的来说，这些动脉变化是常规检测不到的 肱动脉压的临床测量并且独立于 性别，但与运动能力成反比。 值得注意的是，还有一点是 对于身体状况良好的老年人（> 60 岁） 动脉僵硬度和反射波指数显着降低，并且 与年轻人没有什么不同，尽管与年龄相关 收缩压持续升高。 我们已主动采取行动 将其中许多研究扩展到美国黑人和其他非西方国家 发生不同动脉压变化模式的人群 与老龄化（在中国通过研究合同）。