AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

血管硬度特性与年龄相关的变化

• 批准号: 2565668
• 负责人: E LAKATTA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2565668
• 关键词: adult human (21+); aerobic exercise; aging; angiocardioultrasonography; arteriosclerosis; blood pressure; body composition; cardiovascular disorder epidemiology; carotid artery; clinical research; hormone therapy; human subject; myocardium; pulse pressure wave; sex hormones; somatotropin; vascular resistance

The ultimate goals of this project are to determine how arterial stiffness properties influence myocardial structure and function and contribute to cardiovascular morbidity and mortality. A. To determine whether ultrasonic indices of carotid arterial structure are major determinants of arterial stiffness properties, we measured thickness and diameter of the common carotid artery (CCA) from B-mode ultrasonography and the augmentation index (AGI), derived from applanation tonometry of the CCA, in 84 healthy normotensive BLSA volunteers aged 27-95 years. Although systolic blood pressure (r=0.31), CCA thickness (r=0.58), CCA systolic diameter (r=0.30), and AGI/height (r=0.43) all correlated directly with age, AGI/height did not correlate with either ultrasonic measurement. In addition, AGI/height was unrelated to four elasticity indices derived from CCA ultrasound, distensibility coefficient, cross-sectional compliance, pressure-strain ela ic modulus, and young's modulus. B To determine whether growth hormone or sex steroid supplementation ameliorates arterial stiffness properties in older adults with deficiencies of these substances, we are measuring pulse wave velocity and AGI in men and women aged 65 years and older, before and after hormonal replacement. C. We are testing the hypothesis that 1-2 years of home-based aerobic exercise training can reduce arterial stiffness in the muylticenter NIH-sponsored Activities Counseling Trial of 810 subjects 35-75 years old. D. We have examined the contribution of arterial stiffness to left ventricular (LV) mass in 695 men and 616 women from Taiwan (Contract #N01-AG-02-2118). In both sexes, the major predictors of LV mass were systolic blood pressure, body surface area and age; AGI contributed minimally (r2less than or equal to 0.006) to LV mass in either sex. E. A multicenter study to determine whether arterial stiffness is an independent risk factor for cardiovascular events in elderly free-living persons has been developed by the Epidemiology Demography Biometry Program of the intramural NIA. F. A method for calculation of charteristic impedance of the arterial tree from non-invasiv measurements of central arterial pressure and flow has recently been developed. G. We are performing follow-up measurements of arterial stiffness on endurance trained older men and their sedentary age peers, initially studied in 1989-1991 to determine whether chronic endurance training attenuates the normal age-associated increase in arterial stiffness. H. To determine whether aerobic exercise training can reduce the elevated arterial stiffness of older heart failure patients and whether such changes in arterial stiffness are related to training-induced improvement of aerobic performance, we will measure arterial stiffness and peak VO2 before and after a 3 month program of aerobic training.

本项目的最终目标是确定动脉僵硬度 性质影响心肌结构和功能，并有助于 心血管疾病发病率和死亡率。A.以确定是否超声波 颈动脉结构指数是动脉粥样硬化的主要决定因素， 刚度特性，我们测量的厚度和直径的共同 颈动脉B超及增强 采用颈总动脉压平眼压测量法测定84例健康人颈总动脉压指数（AGI）， 年龄27-95岁的血压正常的BLSA志愿者。 虽然收缩期血 压力（r=0.31）、颈总动脉厚度（r=0.58）、颈总动脉收缩期内径（r=0.30）、 AGI/身高（r=0.43）与年龄呈正相关，AGI/身高与年龄呈负相关。 与超声波测量无关。 此外，AGI/身高 与颈总动脉超声的四项弹性指标无关， 膨胀系数，截面柔度，压力-应变弹性模量，弹性模量 IC 弹性模量和杨氏模量。B确定生长激素 或性类固醇补充剂改善动脉僵硬特性， 老年人缺乏这些物质，我们测量脉搏 年龄在65岁及以上的男性和女性的波速度和AGI， 以及激素替代治疗后。C.我们正在测试假设1-2 多年的家庭有氧运动训练可以减少动脉 多中心NIH赞助的活动咨询试验中的僵硬， 810例35-75岁的受试者。D.我们研究了 695名男性和616名女性的动脉硬度与左心室（LV）质量的关系 来自台湾（合同编号N 01-AG-02-2118）。无论男女， 左室质量的预测因子为收缩压、体表面积 AGI对LV的贡献最小（r2小于或等于0.006） 在任何性别的质量。E.一项多中心研究，以确定是否动脉 僵硬是心血管事件的独立危险因素， 老年人自由生活的人已经制定了流行病学 NIA内部人口统计学生物统计学项目。F.的方法 无创性动脉树特征阻抗的计算 最近，中心动脉压和流量的测量已经被 开发G.我们正在进行动脉的后续测量， 对耐力训练的老年人和他们久坐不动的同龄人的僵硬， 最初是在1989-1991年进行的研究， 训练减弱了与年龄相关的动脉粥样硬化的正常增加， 刚度H.为了确定有氧运动训练是否可以减少 老年心力衰竭患者动脉僵硬度升高， 动脉硬度的这种变化与训练引起的 有氧运动能力的改善，我们将测量动脉僵硬度， 峰值VO 2之前和之后3个月的有氧训练计划。