AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

这个项目的最终目标是确定动脉僵硬 属性影响心肌结构和功能，并有助于 心血管发病率和死亡率。A.确定超声波是否 颈动脉结构指标是动脉的主要决定因素 硬度属性，我们测量了厚度和直径的共同 颈动脉(CCA)的B型超声及增强 84例健康人颈总动脉压平眼压指数(AGI) 血压正常的BLSA志愿者，年龄27-95岁。虽然收缩压血 压力(r=0.31)、颈总动脉厚度(r=0.58)、颈总动脉收缩内径(r=0.30)、 AGI/身高(r=0.43)与年龄呈正相关，AGI/身高呈正相关 与两种超声测量结果都不相关。此外，AGI/高度 与CCA超声得出的4个弹性指数无关， 膨胀系数、截面柔度、压力-应变弹性体 集成电路 和杨氏模数。B以确定生长激素是否 或性类固醇补充剂改善大鼠动脉僵硬特性 老年人缺乏这些物质，我们正在测量脉搏 65岁及以上男性和女性的波速和AGI 在荷尔蒙替代后。C.我们正在检验假设1-2 多年的家庭有氧运动训练可以减少动脉血流量 美国国立卫生研究院赞助的多中心活动咨询试验中的僵硬 受试者810人，年龄35-75岁。D.我们审查了 695名男性和616名女性的动脉僵硬与左心室质量的关系 来自台湾(合同编号N01-AG-02-2118)。无论男女，少校 预测左心室重量的指标是收缩压、体表面积 年龄；AGI对LV的贡献最小(r2小于或等于0.006) 无论男女都是弥撒。E.一项多中心研究以确定动脉 僵硬是心血管事件的独立危险因素 老年人自由生活是由流行病学发展起来的 NIA内部的人口学生物测量计划。F.一种解决问题的方法 非侵入性动脉树特征阻抗的计算 最近对中心动脉压力和流量的测量 发展起来的。G.我们正在对动脉进行后续测量 受过耐力训练的老年男性及其久坐不动的同龄人， -1991年初步研究确定慢性耐力是否 训练可减缓正常年龄相关动脉的增加 僵硬。H.确定有氧运动训练是否可以减少 老年心力衰竭患者动脉僵硬程度的升高以及 动脉僵硬的这种变化与训练诱导的 有氧运动能力的改善，我们将测量动脉僵硬和 在为期3个月的有氧训练前和训练后的VO2峰值。

The ultimate goals of this project are to determine how arterial stiffness properties influence myocardial structure and function and contribute to cardiovascular morbidity and mortality. A. To determine whether ultrasonic indices of carotid arterial structure are major determinants of arterial stiffness properties, we measured thickness and diameter of the common carotid artery (CCA) from B-mode ultrasonography and the augmentation index (AGI), derived from applanation tonometry of the CCA, in 84 healthy normotensive BLSA volunteers aged 27-95 years. Although systolic blood pressure (r=0.31), CCA thickness (r=0.58), CCA systolic diameter (r=0.30), and AGI/height (r=0.43) all correlated directly with age, AGI/height did not correlate with either ultrasonic measurement. In addition, AGI/height was unrelated to four elasticity indices derived from CCA ultrasound, distensibility coefficient, cross-sectional compliance, pressure-strain ela ic modulus, and young's modulus. B To determine whether growth hormone or sex steroid supplementation ameliorates arterial stiffness properties in older adults with deficiencies of these substances, we are measuring pulse wave velocity and AGI in men and women aged 65 years and older, before and after hormonal replacement. C. We are testing the hypothesis that 1-2 years of home-based aerobic exercise training can reduce arterial stiffness in the muylticenter NIH-sponsored Activities Counseling Trial of 810 subjects 35-75 years old. D. We have examined the contribution of arterial stiffness to left ventricular (LV) mass in 695 men and 616 women from Taiwan (Contract #N01-AG-02-2118). In both sexes, the major predictors of LV mass were systolic blood pressure, body surface area and age; AGI contributed minimally (r2less than or equal to 0.006) to LV mass in either sex. E. A multicenter study to determine whether arterial stiffness is an independent risk factor for cardiovascular events in elderly free-living persons has been developed by the Epidemiology Demography Biometry Program of the intramural NIA. F. A method for calculation of charteristic impedance of the arterial tree from non-invasiv measurements of central arterial pressure and flow has recently been developed. G. We are performing follow-up measurements of arterial stiffness on endurance trained older men and their sedentary age peers, initially studied in 1989-1991 to determine whether chronic endurance training attenuates the normal age-associated increase in arterial stiffness. H. To determine whether aerobic exercise training can reduce the elevated arterial stiffness of older heart failure patients and whether such changes in arterial stiffness are related to training-induced improvement of aerobic performance, we will measure arterial stiffness and peak VO2 before and after a 3 month program of aerobic training.