USE OF AN IN VIVO MODEL SYSTEM TO INVESTIGATE NIDDM

年龄是NIDDM的独立危险因素。 年龄也与 胰岛素分泌下降 使用来自Wistar大鼠的6-细胞， 老年大鼠群体在GRC，我们表明，胰岛素释放的反应， 随着年龄的增长，葡萄糖的浓度降低。这是由于beta更少 释放胰岛素的细胞以及每个细胞释放的胰岛素较少。我们 发现胰岛素的mRNA在胰岛中优先减少， 葡萄糖激酶和胰高血糖素信息不受影响。因此，看来， 在大鼠的整个生命周期中，胰岛素信息在减少。胰岛 通过增加尺寸来补偿。但是，最终这种补偿 变得不足。因此，可以想象当施加压力时， 所以需要更多的胰岛素，糖尿病可能会导致。我们 探索是什么因素导致胰岛素信息的减少， 我们可以阻止或逆转它。

Age is an independent risk factor for NIDDM. Age is also associated with a decline in insulin secretion. Using 6-cells from Wistar rats from the colony of aged rats at the GRC, we showed that insulin release in response to glucose decreases with age of the donor. This is a result of fewer beta cells releasing insulin as well as less insulin released per cell. We found that mRNA for insulin is preferentially diminished in islets, with glucokinase and glucagon messages unaffected. Therefore, it appears that throughout the lifespan of the rat, insulin message is decreasing. Islets compensate for this by increasing size. But, eventually this compensation becomes inadequate. Therefore, one can envision when a stress is put on the system so more insulin is required, diabetes could result. We are exploring what factors lead to this diminution of insulin message and the possibility that we can prevent or reverse it.