AGING AND THE PANCREAS

衰老与胰腺

• 批准号: 2333496
• 负责人: J EGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2333496
• 关键词: aging; disease /disorder model; drug delivery systems; glucagon; glucose metabolism; hormone regulation /control mechanism; incretin hormone; insulin; laboratory rat; noninsulin dependent diabetes mellitus; pancreas; pancreatic islet function; peptide analog; somatostatin

Aging is associated with an increased incidence of Type 11 diabetes mellitus. On looking at the characteristics of the age-related decline in insulin secretion that occurs with aging, it appears that the abnormality in insulin secretion that occurs in diabetes is an exaggeration of normal aging processes, coupled with increasing demand for insulin release in the setting of insulin resistance. Of great interest is the new information tha these changes can be reversed. We treated young (6 months) and old (23 months) Wistar rats with an infusion of human recombinant GLP-1 (1.5 pmol per kg body weight per minute) using an ALZET osmotic pump (1003D) implanted subcutaneously in the neck for 48 hours. Insulin mRNA was increased 3 fold in the GLP-1 infused animals. Even the old rats, which have a lower amount of mRNA (50% lower) for insulin than young rats, had a 3 fold increase in insulin mRNA. The abnormality in the insulin secretion with aging was also normalized by this treatment. Of great interest is the fact that beta cells can be induced to proliferate and perhaps new beta cells can be derived from precursor cells by stimulation with GLP-1.

衰老与11型糖尿病的发病率增加有关