USE OF AN IN VIVO MODEL SYSTEM TO INVESTIGATE NIDDM

年龄是NIDDM的独立危险因素。胰岛素的下降 随着年龄的增长，胰岛素的分泌和作用会减少。这 两者的结合使人们更容易患上NIDDM。一种类似的 这种现象发生在Wistar大鼠身上。我们使用的是来自 Wistar大鼠在GRC老年群体中研究胰岛素的变化 分泌物。我们发现胰岛素的信使核糖核酸优先减少 胰岛，葡萄糖激酶和胰升糖素信息不受影响。因此， 人们可以想象，当系统受到压力时，会有更多的胰岛素 如果需要，可能会导致糖尿病。我们正在探索是什么因素导致 胰岛素信息的减少以及我们可以 防止或逆转它。我们发现GLP-1可以在一定程度上恢复 再次响应的单元格数量。

Age is an independent risk factor for NIDDM. A decline in insulin secretion and a decrease in insulin action occur as people age. This combination makes people more prone to develop NIDDM. A similar phenomenon occurs in Wistar rats. We are using the beta cells from Wistar rats in the aged colony at the GRC to study changes with insulin secretion. We found that mRNA for insulin is preferentially diminished in islets, with glucokinase and glucagon messages unaffected. Therefore, one can envision when a stress is put on the system so more insulin is required, diabetes could result. We are exploring what factors lead to this diminution of insulin message and the possibility that we can prevent or reverse it. We have found the GLP-1 can somewhat restore the number of cells that are again responsive.