ROLE OF THE OUTER CAPSID PROTEIN OF HUMAN ROTAVIRUSES IN INFECTIVITY

人类轮状病毒外衣壳蛋白在感染中的作用

• 批准号: 3809737
• 负责人: G LARRALDE
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3809737
• 关键词: Rotavirus; binding proteins; insect virus; virus envelope; virus infection mechanism; virus protein; virus receptors

The binding of the VP4 protein to MA 104 cells, a permissive host for rotavirus infection, was demonstrated using lysates of insect Spodoptera frugiperda (Sf9) cells that had been infected with a recombinant baculovirus expressing the VP4 gene of human rotavirus strain KU, DS-1, or 1076. Moreover, binding assays using the in vitro expressed VP5 or VP8 subunit of VP4, indicated that VP5 and not VP8 was responsible for the binding of the VP4 protein to a susceptible host cell.

VP4蛋白与MA - 104细胞结合，MA - 104细胞是一种允许宿主