The UK Photoacoustic Standardisation (PAS) Network

英国光声标准化 (PAS) 网络

• 批准号: EP/V027069/1
• 负责人: Sarah Bohndiek
• 金额: $ 18.18万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV027069%2F1
• 关键词: UK; Photoacoustic; Standardisation; PAS; Network

Photoacoustic imaging (PAI) is an emerging biomedical imaging technology that combines the high contrast of optical imaging with the spatio-temporal resolution of ultrasound, providing an exciting new platform for localised imaging in both animal models and patients. The UK has a strong track record in pioneering PAI, from the creation of new hardware to advancing the state-of-the-art of the technology (e.g. at University College London and King's College London), through the conception of new contrast agents for targeted molecular PAI (e.g. at University of Liverpool and University of Leeds) to the validation and application of PAI in living subjects, including animal and human clinical trials (e.g. at University of Cambridge and University of Manchester). These efforts have already received substantial UKRI and charity funding, as well as investment from industry, and are poised to deliver impact in patients, with potential to aid in studies of cancer, Crohn's disease and arthritis, as well as other medical conditions.Translating the technology from the laboratory into the clinic requires technical and biological validation studies that have so far been hindered by a lack of widely accepted test objects and methods, representing an area of unmet research need. Accurate, reproducible and standardised comparisons of the performance of different instruments are vital for quality assurance and control in a hospital setting, as well as for evaluation of the precision and accuracy with which PAI measurements can be made. We propose here to unite the multidisciplinary UK PAI community into an EPSRC Network to stimulate new efforts in this research area, by bringing together researchers, government laboratories and industrial partners and enabling mobility and ideas exchange between these stakeholders. By forming a new multidisciplinary research community encompassing technology and methodology development as well as preclinical and clinical applications of PAI, we anticipate significant opportunities for future collaborations and new multidisciplinary research proposals that will drive the field of PAI towards application in healthcare systems. By training of the next-generation of PAI researchers and equipping them with the tools of standardisation, we expect the activities of UK-PAS to permeate the PAI community globally. The primary impact will be to more rapidly advance clinical translation of PAI.

光声成像（PAI）是一种新兴的生物医学成像技术，它将光学成像的高对比度与超声的时空分辨率相结合，为动物模型和患者的局部成像提供了一个令人兴奋的新平台。英国在开创性 PAI 方面拥有良好的记录，从创建新硬件到推进最先进的技术（例如在伦敦大学学院和伦敦国王学院），通过针对靶向分子 PAI 的新型造影剂的概念（例如在利物浦大学和利兹大学），到在活体受试者中验证和应用 PAI，包括动物和人体临床试验（例如在剑桥大学） 和曼彻斯特大学）。这些努力已经获得了 UKRI 和慈善机构的大量资金以及来自工业界的投资，并有望对患者产生影响，并有可能有助于癌症、克罗恩病和关节炎以及其他医疗状况的研究。将技术从实验室转化为临床需要技术和生物验证研究，但迄今为止，由于缺乏广泛接受的测试对象和方法，这些研究受到了阻碍，这代表了一个未满足研究需求的领域。对不同仪器的性能进行准确、可重复和标准化的比较对于医院环境中的质量保证和控制以及评估 PAI 测量的精度和准确度至关重要。我们在此建议将多学科的英国 PAI 社区联合到 EPSRC 网络中，通过将研究人员、政府实验室和工业合作伙伴聚集在一起，并促进这些利益相关者之间的流动和思想交流，来刺激该研究领域的新努力。通过形成一个涵盖 PAI 技术和方法开发以及临床前和临床应用的新的多学科研究社区，我们预计未来的合作和新的多学科研究提案将带来重大机会，这将推动 PAI 领域在医疗保健系统中的应用。通过培训下一代 PAI 研究人员并为他们配备标准化工具，我们预计 UK-PAS 的活动将渗透到全球 PAI 社区。主要影响将是更快地推进 PAI 的临床转化。

项目成果

A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption.

• DOI: 10.1016/j.pacs.2023.100539
• 发表时间: 2023-08
• 期刊: PHOTOACOUSTICS
• 影响因子: 7.9
• 作者: Assi, Hisham;Cao, Rui;Castelino, Madhura;Cox, Ben;Gilbert, Fiona J.;Gro, Janek;Gurusamy, Kurinchi;Hacker, Lina;Ivory, Aoife M.;Joseph, James;Knieling, Ferdinand;Leahy, Martin J.;Lilaj, Ledia;Manohar, Srirang;Meglinski, Igor;Moran, Carmel;Murray, Andrea;Oraevsky, Alexander A.;Pagel, Mark D.;Pramanik, Manojit;Raymond, Jason;Singh, Mithun Kuniyil Ajith;Vogt, William C.;Wang, Lihong;Yang, Shufan;Bohndiek, Sarah E.
• 通讯作者: Bohndiek, Sarah E.

The IPASC data format: A consensus data format for photoacoustic imaging.

• DOI: 10.1016/j.pacs.2022.100339
• 发表时间: 2022-06
• 期刊: Photoacoustics
• 影响因子: 7.9
• 作者: Gröhl J;Hacker L;Cox BT;Dreher KK;Morscher S;Rakotondrainibe A;Varray F;Yip LCM;Vogt WC;Bohndiek SE;Members of the International Photoacoustic Standardisation Consortium (IPASC)
• 通讯作者: Members of the International Photoacoustic Standardisation Consortium (IPASC)

A Stable Phantom Material for Optical and Acoustic Imaging.

用于光学和声学成像的稳定模体材料。

• DOI: 10.3791/65475
• 发表时间: 2023
• 期刊: JoVE
• 作者: Hacker L