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Multidimensional endoscopy for early cancer detection

多维内窥镜检查用于早期癌症检测

基本信息

批准号：
EP/R003599/1
负责人：
Sarah Bohndiek
金额：
$ 156.92万
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FR003599%2F1
关键词：
Multidimensional endoscopy early cancer detection

项目摘要

Each year in the UK, over 55,000 patients will be diagnosed with oesophageal or lung cancer; a staggering 44,000 will die from their disease. The majority of patients are currently diagnosed when their disease is at a late stage (with regional or distant spread), yielding less than 10% survival over 5 years. Therefore, a key clinical unmet need remains for early disease diagnosis. To detect these cancers early, patients that are at a high risk of disease might undergo endoscopy. An endoscope is a long, thin, flexible tube with a light source and video camera at one end to relay images from inside the body. They replicate what our eye could see if we were able to look inside the body. Endoscopy is vital for surveillance and diagnosis of cancer, however, many cancers of the oesophagus (food pipe) and lung start out as small abnormalities that are hard to spot using conventional endoscopes.The focus of this research is to augment the vision of the endoscopist by designing a specialist video camera that detects the properties of light that our eyes are blind to. We will also use this new camera in a benchtop system that can analyse tissue that has been taken out of the body (biopsied) very quickly, before it is sent to a pathologist to check for cancer. Our new cameras are designed to be cost effective and provide extra information to help doctors with diagnosing cancer in the oesophagus and lung, and could ultimately replace the current standard-of-care.

在英国，每年将有超过55，000名患者被诊断患有食管癌或肺癌;令人震惊的是，44，000人将死于这种疾病。目前大多数患者在疾病处于晚期（区域或远处扩散）时被诊断出来，5年生存率不到10%。因此，一个关键的临床未满足的需求仍然是早期疾病诊断。为了早期发现这些癌症，疾病风险高的患者可能会接受内窥镜检查。内窥镜是一种长而细的柔性管，一端有光源和摄像机，用于传递体内的图像。它们复制了我们的眼睛所能看到的东西，如果我们能够看到身体内部的话。内窥镜检查对于癌症的监测和诊断至关重要，然而，许多食道（食物管道）和肺癌的癌症开始时都是很小的异常，使用传统内窥镜很难发现。本研究的重点是通过设计一种专门的摄像机来增强内窥镜医生的视力，该摄像机可以检测我们眼睛无法识别的光的特性。我们还将在台式系统中使用这种新相机，该系统可以非常快速地分析从体内取出的组织（活检），然后将其发送给病理学家检查癌症。我们的新摄像头设计具有成本效益，并提供额外的信息，以帮助医生诊断食道和肺部癌症，并最终取代目前的标准护理。