STRESS, VIRAL & IMMUNE FACTORS IN EARLY ILLNESS ONSET

压力，病毒式传播

• 批准号: 3069795
• 负责人: DAVID A. MRAZEK
• 金额: $ 5.94万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3069795
• 关键词: asthma; behavior test; child (0-11); child behavior; child psychology; coping; emotional adjustment; emotions; interview; parent offspring interaction; preschool child (1-5); psychological stressor

This proposal is for an ADAMHA Research Scientist Development Award - Level I to study the process of emotional regulation in a sample of young children who have experienced severe early life stress. The RSDA would provide me the opportunity to obtain specific research training that is critical for the implementation of the described systematic research program to study serious emotional disturbances in chronically ill children. The specific stressful stimuli that will be studied are severe asthma (an illness characterized by repeated reversible frightening attacks of the inability to breathe) and early multiple hospitalizations. The initial goal is to document specific problems in emotional regulation in young severely asthmatic children (36 to 72 months of age) who have experienced repeated hospitalizations. An experimental paradigm will be used to elicit parent-child interactions that are coded using a sequential scoring system that highlights the affective content of parent and child responses. A severely asthmatic outpatient sample will be studied to examine the effects of severe asthmatic symptoms without the confound of early hospitalization. A sample of children with corrected congenital cardiac abnormalities will also be studied to examine the effects of early hospitalizations without chronic disability or sudden severe respiratory attacks. A third sample of healthy children matched for age, sex, and socioeconomic status will be studied to better understand the processes of early emotional regulation in normal children and to provide a contrast to the clinical samples. Finally, a prospective study is planned to examine the relative effects of genetic, physiologic, allergic, and emotional influences on children at risk for asthma and will investigate the relationship between emotional regulation and prognosis in children who develop the illness.

本提案是ADAMHA研究科学家发展奖-级别 我想研究一个年轻人的情绪调节过程， 经历过严重的早期生活压力的儿童。 RSDA将 为我提供了获得特定研究培训的机会， 关键的实施所描述的系统研究 研究慢性病患者严重情绪障碍的计划 孩子 将研究的具体应激刺激是严重的 哮喘（一种以反复可逆的可怕发作为特征的疾病 无法呼吸）和早期多次住院。 的 最初的目标是记录情绪调节中的具体问题， 患有严重哮喘的年轻儿童（36至72个月）， 反复住院治疗。 一个实验范例将是 用于引出使用序列 评分系统，突出父母和孩子的情感内容 应答 将研究严重哮喘门诊患者样本， 检查严重哮喘症状的影响， 早期住院。 一个样本的儿童纠正先天性 还将研究心脏异常，以检查早期 无慢性残疾或突发严重呼吸道疾病的住院 攻击 第三组健康儿童的年龄、性别和年龄相匹配， 将研究社会经济状况，以更好地了解 正常儿童的早期情绪调节， 临床样本。 最后，计划进行一项前瞻性研究， 遗传、生理、过敏和情绪的相关影响 对儿童哮喘风险的影响，并将调查 儿童情绪调节与预后的关系 发展成疾病。