EARLY INTERVENTION IN SCHIZOPHRENIA

精神分裂症的早期干预

• 批准号: 3567447
• 负责人: MARVIN I HERZ
• 金额: $ 35.02万
• 依托单位: NEW YORK STATE OFFICE OF MENTAL HEALTH
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3567447
• 关键词: chemoprevention; community mental health services; computer data analysis; data collection; disease /disorder proneness /risk; drug adverse effect; family structure /dynamics; family therapy; group therapy; health care cost /financing; health education; health service demonstration project; hospital utilization; human subject; human therapy evaluation; mental disorder chemotherapy; mental disorder diagnosis; mental disorder prevention; mental health counseling; mental health facility; psychotherapy; quality of life; questionnaires; relapse /recurrence; schizophrenia; sign /symptom; social adjustment; social support network

The purpose of this demonstration project is to determine whether an Early Intervention Strategy is effective in reducing relapse and rehospitalization rates in schizophrenic patients who have recently been discharged from the hospital and are at high risk for relapse. Patients will be randomly assigned to an experimental and control group: The Early Intervention Strategy experimental group will receive 1) Education of patients and family members about prodromal symptoms of relapse and 2) Immediate intervention with increased medication and supportive crisis therapy when prodromal symptoms appear until the episode resolves. There is close collaboration between patients, family members, and treatment personnel. The control group will receive Treatment as Usual (individual medication management and support bi-weekly) as outpatients. The relative efficacy of these two treatment programs will be compared over an 18-month period with respect to relapse and rehospitalization rates, major dimensions of psychopathology, social and vocational role functioning, family burden, patient and family satisfaction, patient quality of life, drug side effects and cost effectiveness. It is hypothesized that 1) The rates of relapse and rehospitalization will be statistically significantly higher for patients in the Treatment as Usual Group as compared to patients in the Early Intervention Strategy Group after 18 months. 2) Patients in the Early Intervention Strategy Group will have significantly decreased symptomatology, better social and vocational role functioning, decreased drug side effects, better quality of life, and more satisfaction with treatment, and families will show decreased family burden and more satisfaction with treatment than those in the Treatment as Usual Group. 3) It will be significantly less costly to treat patients in the Early Intervention Strategy Group than the Treatment as Usual Group, the main reason being much reduced hospitalization in the EIS group. Significance: If relapse and rehospitalization rates in schizophrenic patients can be reduced, it will be a great public health benefit and patients will have a sense of control over the course of their illness.

这个示范项目的目的是确定早期的 干预策略在减少复发和减少复发方面有效 最近住院的精神分裂症患者的再住院率 出院了，复发的风险很高。病人 将被随机分配到试验组和对照组：早期 干预策略试验组将接受1)教育 患者和家属关于复发的前驱症状和2) 立即进行干预，增加药物治疗和支持性危机 先兆症状出现直至症状消失的治疗。那里 是患者、家属和治疗人员之间的密切合作 人事部。对照组将照常接受治疗(个别 每两周进行一次药物管理和支持)。相对的 这两个治疗方案的疗效将在18个月内进行比较 在复发和再住院率方面，主要 精神病理学、社会和职业角色功能的维度， 家庭负担、患者和家庭满意度、患者生活质量、 药物副作用和成本效益。 假设1)复发率和再住院率将 在统计上显著高于AS治疗中的患者 平常组与患者的早期干预策略比较 18个月后组。2)患者的早期干预策略 组的症状将显著减少，社会和 职业作用发挥，减少药物副作用，更好的质量 生活，以及对治疗的更多满意度，和家人都会表现出 减少了家庭负担，对治疗的满意度比 治疗组按常规治疗。3)这将大大降低成本 早期干预策略组患者治疗效果好于治疗 像往常一样，主要原因是住院人数大幅减少 EIS组。 意义：如果精神分裂症患者的复发和再住院率 可以减少病人，这将是一个巨大的公共卫生利益和 患者将对他们的疾病过程有一种控制感。