Contribution of Bcl-2 pro-survival proteins to cancer associated with dysregulated autophagy

Bcl-2 促生存蛋白对与自噬失调相关的癌症的贡献

• 批准号: nhmrc : 1049949
• 负责人: Dr Erinna Lee
• 金额: $ 28.53万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-bcl-2-dysregulated-autophagy/112128
• 关键词: Contribution; Bcl; pro; survival; proteins

Cell survival and death are controlled by two processes known as apoptosis and autophagy. Apoptosis eliminates damaged cells whereas autophagy gets rid of faulty components in the cell. The Bcl-2 proteins regulate both processes. It is well established that dysfunctional Bcl-2 regulation leads to cancer. In this project, we aim to investigate if deregulated Bcl-2 control of autophagy also has a key role in cancer progression and to obtain a molecular picture of how this control is exerted.

细胞的存活和死亡由两个过程控制，称为凋亡和自噬。细胞凋亡消除受损细胞，而自噬则清除细胞中的缺陷成分。Bcl-2蛋白调节这两个过程。众所周知，Bcl-2调节功能失调会导致癌症。在这个项目中，我们的目标是研究Bcl-2对自噬的失调控制是否也在癌症进展中起关键作用，并获得这种控制如何发挥作用的分子图像。