Role of the Mitochondrial Membrane in Apoptosis

线粒体膜在细胞凋亡中的作用

• 批准号: nhmrc : 1084648
• 负责人: Dr Erinna Lee
• 金额: $ 35.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mitochondrial-membrane-apoptosis/519021
• 关键词: Role; Mitochondrial; Membrane; Apoptosis

The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. They target the mitochondrial outer membrane where they interact to determine cell fate. We will evaluate the membrane interactions of the Bcl-2 proteins in complementary biophysical and cellular experiments to redefine our understanding of the mechanism of apoptosis and provide new avenues for the development of compounds to selectively modulate diseases in which apoptosis is unregulated.

Bcl-2蛋白家族对细胞凋亡（一种程序性细胞死亡）调节至关重要。它们靶向线粒体外膜，在那里它们相互作用以决定细胞命运。我们将评估Bcl-2蛋白在互补的生物物理和细胞实验中的膜相互作用，以重新定义我们对细胞凋亡机制的理解，并为开发化合物选择性地调节细胞凋亡不受调节的疾病提供新的途径。