Role of the Mitochondrial Membrane in Apoptosis

Bcl2蛋白家族对细胞凋亡(细胞程序性死亡的一种形式)的调控至关重要。它们以线粒体外膜为靶点，在那里它们相互作用，决定细胞的命运。我们将在互补的生物物理和细胞实验中评估Bcl2蛋白的膜相互作用，以重新定义我们对细胞凋亡机制的理解，并为开发选择性调节细胞凋亡未调控的疾病的化合物提供新的途径。

The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. They target the mitochondrial outer membrane where they interact to determine cell fate. We will evaluate the membrane interactions of the Bcl-2 proteins in complementary biophysical and cellular experiments to redefine our understanding of the mechanism of apoptosis and provide new avenues for the development of compounds to selectively modulate diseases in which apoptosis is unregulated.