Targeting apoptotic pathways for the treatment of schistosomiasis

靶向细胞凋亡途径治疗血吸虫病

• 批准号: nhmrc : 1024620
• 负责人: Dr Erinna Lee
• 金额: $ 27.23万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-apoptotic-pathways-treatment-schistosomiasis/110366
• 关键词: Targeting; apoptotic; pathways; treatment; schistosomiasis

Schistosomiasis is a disease caused by parasites known as schistosomes. As the current use of a single drug could lead to resistance, there is an urgency for new drugs. I discovered a novel cell death machinery in schistosomes and I now aim to unravel how this cell death pathway works and to identify the players required for parasite survival. The next step will then be to develop molecules that neutralize the activity of these pro-survival molecules hence leading to parasite death.

血吸虫病是一种由寄生虫引起的疾病。由于目前单一药物的使用可能导致耐药性，因此迫切需要新药。我在寄生虫体内发现了一种新的细胞死亡机制，我现在的目标是解开这种细胞死亡途径是如何工作的，并确定寄生虫生存所需的参与者。下一步将是开发中和这些促生存分子活性的分子，从而导致寄生虫死亡。