Contribution of orexin receptors to the cardiovascular response of psychological stress

食欲素受体对心理应激心血管反应的贡献

• 批准号: nhmrc : 1024891
• 负责人: A/Pr Matthias Klugmann
• 金额: $ 27.25万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-orexin-receptors-psychological-stress/110385
• 关键词: Contribution; orexin; receptors; cardiovascular; response

Anxiety, fear of challenges, frustration are part of modern life stressors. Our body reacts to these stressors by increasing blood pressure and heart rate, which in turn can harm our cardiovascular system and precipitate cardiovascular accidents. In this project we test a new class of drugs that act on a neurochemical system implicated in these particular responses. If our hypothesis is correct, one of these drugs could be used to relax the cardiovascular system and protect it in times of stress.

焦虑，害怕挑战，挫折是现代生活压力的一部分。我们的身体通过增加血压和心率对这些压力源做出反应，这反过来会损害我们的心血管系统并引发心血管事故。在这个项目中，我们测试了一类新的药物，它们作用于与这些特定反应有关的神经化学系统。如果我们的假设是正确的，这些药物中的一种可以用来放松心血管系统，并在压力下保护它。