Viral-mediated modulation of BDNF expression in motor neurons to promote the recovery of hand/digits function in a rat model of spinal cord injury that impairs normal grasping action.

病毒介导的运动神经元 BDNF 表达调节，可促进损害正常抓握动作的脊髓损伤大鼠模型中手/手指功能的恢复。

• 批准号: nhmrc : 1048764
• 负责人: A/Pr Matthias Klugmann
• 金额: $ 22.77万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-mediated-modulation-grasping-action/112036
• 关键词: Viral; mediated; modulation; BDNF; expression

This project seeks to lure injured axons towards motor neurons, a process that is essential for the recovery of motor function. BDNF gradients will be created along the injured axons path. Axons will have to elongate to reach the first source of BDNF. They will need to elongate even more to get to the next source of BDNF, hence bringing them each time closer to their lost targets. This gene therapy scenario has the potential to bring gene therapy a step closer for human spinal cord injury.

该项目旨在将受伤的轴突诱导至运动神经元，这一过程对于运动功能的恢复至关重要。BDNF沿损伤轴突路径产生梯度。轴突必须拉长才能到达BDNF的第一个来源。它们需要更长的时间才能找到下一个BDNF来源，因此每次都让它们更接近失去的目标。这种基因治疗方案有可能使基因治疗离人类脊髓损伤更近一步。