Contribution of ovarian cancer stem cells to chemoresistance and recurrent disease.

卵巢癌干细胞对化疗耐药和复发性疾病的贡献。

• 批准号: nhmrc : GNT1081461
• 负责人: A/Pr Pradeep Tanwar
• 金额: $ 36.71万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-ovarian-cancer-recurrent-disease/1345406
• 关键词: Contribution; ovarian; cancer; stem; cells

Ovarian cancer is the most lethal gynaecological cancer. Previously, we showed that cancer stem cells are the “beating heart” of the ovarian cancer and are responsible for drug resistance and tumour relapse. The ineffective targeting of these cells by chemotherapy is accountable for the poor clinical outcomes in ovarian cancer patients. This project will define the molecular signals involved in maintenance of cancer stem cells and develop targeted therapies against these cells.

卵巢癌是最致命的妇科癌症。此前，我们已经证明，癌症干细胞是卵巢癌的“跳动心脏”，并对耐药和肿瘤复发负责。化疗对这些细胞的靶向无效是卵巢癌患者临床结果不佳的原因。该项目将确定参与维持癌症干细胞的分子信号，并针对这些细胞开发有针对性的治疗方法。