SYNTHESIS OF TREATMENT AGENTS FOR COCAINE ADDICTION

该合同的目的是提供快速的化合物资源 作为潜在的治疗剂进行测试。我们在RFP中提出了建议 我们希望在我们的程序中包含的化合物类的类型： 班级： (1)多巴胺摄取抑制剂，如安非他酮和安非他明的类似物 Indatraline； (2)5-羟色胺转运体选择性可卡因类似物； (3)选择性D3、D4、D5激动剂和拮抗剂； (4)选择性D2部分激动剂； (5)非苯扎西平结构的选择性D_1部分激动剂； (6)与多巴胺转运体结合但不抑制的化合物 多巴胺摄取(“多巴胺节制可卡因拮抗剂”)。 承包商应将设计和合成路径提交给 项目官员，谁对哪些化合物做出最终决定，以及 每一个有多少，将被合成。对合成的化合物进行测试 通过CTDP并将数据尽快提供给承包商 变得可用。PO和承包商将就以下事项做出决定 基于数据的放大和未来的复合设计。承包商 保留对其结构和数据的所有权利。 每份合同为期一年，有两个选项年。期权年份 为成功化合物的放大和新化合物的设计提供了条件 化合物。

The purpose of the contract is to provide a rapid resourse of compounds for testing as potential treatment agents. We put suggestions in the RFP of the types of compounds classes we would like to have in our program: Class: (1) Dopamine uptake inhibitors such as analogs of bupropion and indatraline; (2) Serotonin transporter selective cocaine analogs; (3) Selective D3, D4, and D5 agonists and antagonists; (4) Selective D2 partial agonists; (5) Selective D1 partial agonists not based on the benzazepine structure; (6) Compounds that bind to the dopamine transporter that do not inhibit dopamine uptake ("dopamine sparing cocaine antagonists"). The contractor is meant to submit designs and synthetic pathways to the Project Officer, who makes the ultimate decision on which compounds, and how much of each, will be synthesized. Synthesized compounds are tested through the CTDP and data is provided to the contractor as soon as it becomes available. The PO and the contractor will make decisions about scale-up and future compound designs based on the data. The contractor retains all rights to their structures and data. Each contract runs for 1 year with 2 option years. The option years provide for the scale-up of successful compounds and the design of new compounds.